Endometriosis Unveiled: Innovations in Diagnosis and Management of Endometriosis

In: Clinical Obstetrics & Gynecology · 2026 · doi:10.1097/grf.0000000000001045 · W7168135010
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This article reviews current and future diagnostic and management strategies for endometriosis, including novel imaging, biomarkers, AI, nonhormonal treatments, surgical interventions, and behavioral therapies.

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This review article outlines the pathophysiology of endometriosis as a chronic inflammatory condition involving complex pain pathways. It examines current and emerging diagnostic strategies, such as novel imaging, biomarkers, and artificial intelligence integration. The text also covers medical and surgical management options, highlighting new nonhormonal treatments and behavioral interventions alongside future directions in precision medicine. This paper is centrally about endometriosis — specifically providing a comprehensive overview of innovations in its diagnosis and management.

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Abstract

Endometriosis is a chronic inflammatory condition that can result in chronic pain through complex nociceptive, neuropathic, and nociplastic pathways. This article provides a comprehensive background on endometriosis as well as future directions in diagnosis and management. The diagnosis of endometriosis is explored, including novel imaging techniques, biomarkers, and the integration of artificial intelligence. The medical management of endometriosis is reviewed, including a focus on new nonhormonal treatment options. Surgical treatments are reviewed along with surgical outcomes. We discuss nonpharmaceutical and behavioral interventions with growing interest. Finally, this article reviews future directions in endometriosis care, including precision medicine and AI.
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Endometriosis Unveiled: Innovations in Diagnosis and Management of Endometriosis - Hannah Millimet* - Abigail Lee† - Courtney Lim* - Catherine Allaire† - Sawsan As-Sanie* Endometriosis is a chronic inflammatory condition that can result in chronic pain through complex nociceptive, neuropathic, and nociplastic pathways. This article provides a comprehensive background on endometriosis as well as future directions in diagnosis and management. The diagnosis of endometriosis is explored, including novel imaging techniques, biomarkers, and the integration of artificial intelligence. The medical management of endometriosis is reviewed, including a focus on new nonhormonal treatment options. Surgical treatments are reviewed along with surgical outcomes. We discuss nonpharmaceutical and behavioral interventions with growing interest. Finally, this article reviews future directions in endometriosis care, including precision medicine and AI.

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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