Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation

Harmeet Singh, John Aplin, John D Aplin
Journal of anatomy · 2009 · vol. 215(1) , pp. 3–13 · doi:10.1111/j.1469-7580.2008.01034.x · PMID:19453302 · PMC2714633 · W2143108062
Review OA: bronze CC0 ⤵ 14 in-corpus citations
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This review discusses adhesion molecules in endometrial epithelium, focusing on their role in maintaining tissue integrity and facilitating embryo implantation.

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Abstract

Cell adhesion in endometrial epithelium is regulated to maintain the continuity and protectiveness of the luminal covering cell layer while permitting interstitial implantation of the embryo during a restricted period of about 4 days. Many apparently normal embryos fail to implant, and epithelial-embryo adhesion remains a poorly understood phenomenon. After menstruation, epithelial regeneration occurs by epiboly from the basal residues of glands, an activity that requires migration on extracellular matrix as well as cell-cell cohesion. Here we review current knowledge of adhesion molecules in the epithelium.

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MeSH descriptors

Cell Adhesion Molecules Embryo Implantation Endometrium Cadherins Cadherins Cell Adhesion Molecules Embryo Implantation Endometrium Epithelium Epithelium Female Humans Immunoglobulins Immunoglobulins Integrins Integrins

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License: CC0 · commercial use OK