Sanleng Wan inhibits endometriosis progression by regulating sphingolipid metabolism via the S1P/S1PR1-Akt axis based on serum metabolomics and network pharmacology

Zhiyi Fu, Hong Zhou, Hao Liu, Xiaoqiong Li, Lixing Cao, Weilin Zheng
Journal of ethnopharmacology · 2025 · vol. 352 , pp. 120153 · doi:10.1016/j.jep.2025.120153 · PMID:40523453 · W4411306496
article OA: closed CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigates how Sanleng Wan regulates sphingolipid metabolism through the S1P/S1PR1-Akt axis to inhibit endometriosis progression, using serum metabolomics and network pharmacology.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (87)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
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License: CC0 · commercial use OK