Bilaterality of ovarian endometriomas does not affect the outcome of in vitro fertilization/intracytoplasmic sperm injection in infertile women after laparoscopic cystectomy

Hsing-Tse Yu, Hong‐Yuan Huang, Hong-Yuan Huang, Hsiao-Jung Tseng, Hsiao‐Jung Tseng, Chin-Jung Wang, Chin‐Jung Wang, Chyi‐Long Lee, Chyi-Long Lee, Yung-Kuei Soong, Yung‐Kuei Soong
Biomedical journal · 2017 · vol. 40(5) , pp. 295–299 · doi:10.1016/j.bj.2017.06.009 · W2767545563
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This retrospective study found that bilaterality of ovarian endometriomas does not affect IVF/ICSI pregnancy outcomes, though bilateral endometriomas may impair ovarian response compared to unilateral ones.

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Abstract

To assess whether the unilateral or bilateral lesions can affect ovarian reserve and pregnancy outcome in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in infertility patients underwent laparoscopic cystectomy. A total of 148 IVF/ICSI cycle in patients who had undergone laparoscopic cystectomy for unilateral or bilateral endometriomas were reviewed retrospectively. There were 103 cycles where laparoscopic cystectomy had been carried out for unilateral endometriomas and 45 cycles after bilateral-side surgery. Primary outcome measures were ovarian reserve and ovarian response. Secondary outcome measures were the implantation rate, clinical pregnancy rate, and live birth rate. The number of dominant follicle on the day of human chorionic gonadotropin (hCG) administration (5.2 ± 3.1 vs. 4.2 ± 2.7; p = 0.048), and oocytes retrieved (10.0 ± 6.9 vs. 7.6 ± 6.6; p = 0.047) were significantly lower in the bilateral-side group compare with the unilateral-side group. However, the mean number of antral follicle count, metaphase II oocytes, the doses of gonadotropin used, fertilization rate, the rate of good quality embryos transferred, implantation rate and clinical pregnancy, live-birth rate and miscarriage rate were similar between the two groups. There were no associations among the bilaterality of ovarian endometriomas, ovarian reserve and pregnancy outcomes in IVF/ICSI cycles. However, bilateral ovarian endometriomas after laparoscopic cystectomy may impair ovarian response as compared to unilateral ovarian endometrioma.

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Condition tags

mesh:D004715endometriomainfertility

MeSH descriptors

Cystectomy Cystectomy Endometriosis Laparoscopy Laparoscopy Ovarian Reserve Endometriosis Female Humans Ovarian Reserve Pregnancy Pregnancy Outcome Retrospective Studies Sperm Injections, Intracytoplasmic Sperm Injections, Intracytoplasmic

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