Transferrin Receptor (CD71) Expression in Peritoneal Macrophages from Fertile and Infertile Women With and Without Endometriosis

S Martínez-Román, Sergio Martínez‐Román, Juan Balasch, J Balasch, M Creus, Montserrat Creus, F Fábregues, Francisco Fábregues, F Carmona, Francisco Carmona, R Vilella, Juan A. Vanrell, J A Vanrell
American journal of reproductive immunology (New York, N.Y. : 1989) · 1997 · vol. 38(6) , pp. 413–417 · doi:10.1111/j.1600-0897.1997.tb00320.x · PMID:9412724 · W2046888386
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Peritoneal macrophages from infertile women with endometriosis exhibited significantly increased transferrin receptor (CD71) expression compared to three control groups.

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Abstract

PROBLEM: Hyperactivated macrophages are implicated in the pathophysiology of endometriosis-associated infertility. This study investigates transferrin receptor expression (CD71) as a marker of hyperactivity in peritoneal macrophages of infertile patients with minimal to mild endometriosis (group 1, n = 25). METHOD OF STUDY: Expression of the activation antigen CD71 on peritoneal fluid macrophages was determined by a specific monoclonal anti-CD71 antibody using indirect immunofluorescence technique and was analyzed by flow cytometry. Three different control groups of women were used: women with unexplained infertility (group 2, n = 25), fertile women with endometriosis (group 3, n = 10), and fertile women without endometriosis (group 4, n = 25). RESULTS: The percentage of CD71 positive cells was significantly increased in infertile women with endometriosis as compared with the three control groups. There were no differences among groups 2, 3, and 4 with respect to the percentage of CD71 positive macrophages. CONCLUSIONS: Our results favor the concept that hyperactivated macrophages play a role in the pathophysiology of endometriosis-associated subfertility, a feature which is lacking in patients with unexplained infertility.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Macrophages, Peritoneal Receptors, Transferrin Adult Endometriosis Female Humans Infertility, Female Macrophage Activation Macrophages, Peritoneal Macrophages, Peritoneal Receptors, Transferrin

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