Influence of danazol on uterine activity. A pilot study
Other
OA: closed
CC0
⤵ 1 in-corpus citation
AI-generated summary
Danazol treatment in women with endometriosis initially increased uterine activity but then significantly inhibited contractions by affecting gonadotropins and ovarian hormones.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
The influence of danazol treatment on uterine activity was studied by means of repeated intra-uterine pressure recordings in two women with laparoscopically diagnosed endometriosis. During a control cycle the women had normal plasma levels of FSH, LH, estradiol and progesterone and repeated recordings showed a varying uterine activity, with irregular small contractions in the follicular phase and regular ones with maximal amplitude and duration at the onset of menstruation. Treatment with danazol inhibited the fluctuations in circulating gonadotropins and invariably caused low levels of ovarian hormones. Between 2 and 3 weeks after starting treatment there was a period of increased myometrial activity and increased reactivity of the uterus, but thereafter a marked inhibition of the contractions was seen. It is suggested that danazol could be of value in the treatment of painful conditions with excessive uterine activity, such as primary--and to some extent also secondary--dysmenorrhea.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (sparse)
Too few in-corpus citations on either side for a chart; here are the lists.
Cites (3)
- Endogenous levels of prostaglandin F2alpha and its main metabolites in plasma and endometrium of normal and dysmenorrheic women 1978
- Effects of terbutaline on myometrial activity, uterine blood flow, and lower abdominal pain in women with primary dysmenorrhoea 1976
- Hormonal Effects on Human Myometrial Activity 1974
Cited by (1)
References (5)
- Effects of terbutaline on myometrial activity, uterine blood flow, and lower abdominal pain in women with primary dysmenorrhoea via openalex
- Endogenous levels of prostaglandin F2alpha and its main metabolites in plasma and endometrium of normal and dysmenorrheic women via openalex
- Hormonal Effects on Human Myometrial Activity via openalex
- W2029422034 via openalex
- W2047228062 via openalex
Cited by (1)
Source provenance
- europepmc
- last seen: 2026-10-18T09:30:06.152893+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:58:20.576574+00:00
- unpaywall
- last seen: 2026-10-18T06:28:46.490043+00:00
License: CC0
· commercial use OK