High concentrations of magnesium (12 and 24 mM) in the extracellular medium markedly inhibited both spontaneous activity and K+-induced contracture in strips of nonpregnant human myometrium. Net calcium influx measured by the uptake of 45Ca…
Although myometrial activity in the non-pregnant woman is essential for the expulsion of shed endometrium and blood during menstruation, as well as for the transport of sperms or a newly fertilised ovum, myometrial hyperactivity is associat…
The effect of cupric ions on the human uterus and the involvement of prostaglandins (PGs) in mediating this effect was studied by recording of isometric contractions of isolated myometrial strips and pieces of uterine arteries, and by intra…
The influence of danazol treatment on uterine activity was studied by means of repeated intra-uterine pressure recordings in two women with laparoscopically diagnosed endometriosis. During a control cycle the women had normal plasma levels …
The influence of copper ions on myometrial activity was tested in nonpregnant rabbits in vitro and in vivo, and nonpregnant women in vivo. In an organ bath, CuCl2 in concentrations of 3 micro M and higher caused a dose-dependent increase in…
The effects of the selective beta2-receptor stimulator terbutaline (0-25 to 0-5 mg given intravenously) on myometrial activity, local uterine blood flow, and lower abdominal pain were examined during the first day of menstruation in 11 wome…