Infertility: Clinical pregnancy and male subfertility; the ESHRE* multicentre trial on the treatment of male subfertility

P G Crosignani, D E Walters
Human Reproduction · 1994 · vol. 9(6) , pp. 1112–1118 · doi:10.1093/oxfordjournals.humrep.a138642 · PMID:7962385 · W2326635949
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This multicenter trial found that assisted procreation methods like IUI, GIFT, or IVF significantly increased pregnancy rates compared to spontaneous conception or ovulation induction alone in male subfertility cases.

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Abstract

Ovulation induction alone, and ovulation induction in conjunction with one of four assisted procreation methods [intra-uterine insemination (IUI), intra-peritoneal insemination (IPI), gamete intra-Fallopian transfer (GIFT) or in-vitro fertilization (IVF)] were tested as a treatment for male infertility in a prospective randomized trial. The trial when completed had generated data on 499 cycles from 346 patients. There was overwhelming evidence that some form of assisted procreation was beneficial, when compared to the spontaneous natural conception rate, which is generally assumed to be between 0.01 and 0.02 for male infertility. There was also firm evidence that IUI, GIFT or IVF (mean per cycle pregnancy rate 0.212) were superior to the remaining two treatments of IPI and ovulation induction alone (mean per cycle pregnancy rate 0.068). Duration of infertility and a diagnosis of endometriosis were the most important (adverse) pre-treatment factors detected.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Infertility, Male Pregnancy Endometriosis Endometriosis Female Fertilization in Vitro Gamete Intrafallopian Transfer Humans Infertility, Male Insemination, Artificial Insemination, Artificial Male Ovulation Induction Ovulation Induction Prospective Studies Treatment Outcome

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Cited by (4)

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License: CC0 · commercial use OK