Heritage aspects of endometriosis. II. Clinical characteristics of familial endometriosis.

L R Malinak, Malinak Lr, V C Buttram, Buttram Vc, S Elias, Sherman Elias, J L Simpson, Joe Leigh Simpson
American Journal of Obstetrics and Gynecology · 1980 · vol. 137(3) , pp. 332–7 · PMID:7377253 · W2978102740
article OA: closed CC0 ⤵ 81 in-corpus citations
View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Patients with endometriosis and an affected first-degree relative were more likely to have severe disease, suggesting a polygenic/multifactorial etiology.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Clinical characteristics of patients with histologically confirmed pelvic endometriosis who had an affected first-degree relative (N = 18) were compared to those who had no such affected relative (N = 105). The only significant difference was that 61% of individuals in the former group had severe endometriosis, compared to only 24% in the latter group. This observation is most consistent with a polygenic/multifactorial etiology, although other genetic mechanisms cannot be excluded. Our observations carry several important practical implications. First, an apparently unaffected patient with an affected first-degree relative should be counseled that her risk of developing endometriosis is 7%. This might influence the choice of contraception, the timing of pregnancy, and the extent to which aggressive diagnostic approaches (e.g., laparoscopy and curettage) would be appropriate.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Pelvic Neoplasms Adolescent Adult Age Factors Endometriosis Endometriosis Endometriosis Ethnicity Female Fertility Humans Infertility, Female Infertility, Female Pain Pain Pelvic Neoplasms Pelvic Neoplasms Pelvic Neoplasms Time Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (2)

Cited by (50)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:10:10.897782+00:00
License: CC0 · commercial use OK