Joe Leigh Simpson

ORCID: 0000-0002-5309-6881 · 23 papers in corpus · active 1980-2008

Study types

  • article 16
  • review 6
  • letter 1

Condition tags

  • endometriosis 22
  • mesh:D004715 14
  • infertility 2
article 2008
Genetics of Endometriosis
·doi:10.3843/glowm.10363
article 2005
Quantitative DNA perturbations of p53 in endometriosis: analysis of American and Icelandic cases
Fertility and sterility ·doi:10.1016/j.fertnstert.2005.05.031
letter 2005
Where Are the Genes That Cause Endometriosis?
Journal of the Society for Gynecologic Investigation ·doi:10.1016/j.jsgi.2005.02.001
review 2004
Genetic Basis of Endometriosis
Annals of the New York Academy of Sciences ·doi:10.1196/annals.1335.030

Endometriosis is a complex gynecologic disorder that has long been recognized as showing heritable tendencies, with recurrence risks of 5-7% for first-degree relatives. Familial and epidemiologic studies support that this disease is a genet…

review 2004
Genetics of endometriosis: heritability and candidate genes
Best practice & research. Clinical obstetrics & gynaecology ·doi:10.1016/j.bpobgyn.2004.01.004

Endometriosis is a complex gynecologic disorder that affects as many as 10-15% of premenopausal women. Epidemiologic studies have confirmed that this disease is a genetic disorder of polygenic/multifactorial inheritance. The disorder has lo…

article 2004
Protein expression profiling of endometriosis: Validation of 2-mm tissue microarrays
Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.06.044
review 2003
Genetics of endometriosis
Obstetrics and gynecology clinics of North America ·doi:10.1016/s0889-8545(02)00051-7
review 2003
Heritability and candidate genes for endometriosis
Reproductive biomedicine online ·doi:10.1016/s1472-6483(10)61746-4
article 2003
Molecular profiling of endometriosis using tissue microarrays: Disease correlation with increased expression of estrogen receptor-α (ER-α) and decreased expression of progesterone receptor (PR)
·doi:10.1016/s0015-0282(03)01889-2
article 2003
P53 perturbations in endometriosis detected by quantitative real-time PCR: further evidence of late somatic DNA alterations
·doi:10.1016/s0015-0282(03)01896-x
article 2002
Hacia el origen molecular de la endometriosis
review 2002
Heritability and Molecular Genetic Studies of Endometriosis
Annals of the New York Academy of Sciences ·doi:10.1111/j.1749-6632.2002.tb02785.x

Endometriosis is well established as a condition showing heritable tendencies. Polygenic/multifactorial etiology appears far more likely to be the etiology than Mendelian inheritance. The current task is to determine the number and location…

review 2002
Molecular approach to common causes of female infertility
Best practice & research. Clinical obstetrics & gynaecology ·doi:10.1053/beog.2002.0317
article 2002
NAT2 and GSTM1 DNA polymorphisms: increased GSTM1 (active) genotypes in endometriosis
·doi:10.1016/s0015-0282(01)03059-x
article 2002
Somatic DNA alterations in endometriosis: high frequency of chromosome 17 and p53 loss in late-stage endometriosis
Journal of reproductive immunology ·doi:10.1016/s0165-0378(01)00131-0
article 2001
Evaluation of chromosome 17 aneuploidy and p53 loss in endometriosis by fluorescence in situ hybridization (FISH).
·doi:10.1016/s0015-0282(01)02150-1
article 2000
Genetic factors in common disorders of female infertility
·doi:10.1017/s0962279900000314

Female infertility results from a myriad of causes – genetic and nongenetic. Sometimes a genetic aetiology is clearly evident. In other disorders heritable tendencies exist, but the precise genetic aetiology remains obscure. In this communi…

article 1998
Association of N-Acetyltransferase 2 (NAT2) genetic polymorphism resulting in decreased capacity to detoxify aromatic amines in women with endometriosis
·doi:10.1016/s1071-5576(97)86371-x
article 1997
Detection of chromosomal aneuploidy in endometriosis by multi-color fluorescence in situ hybridization (FISH)
Human genetics ·doi:10.1007/s004390050524
article 1984
HLA associations in endometriosis
American Journal of Obstetrics and Gynecology ·doi:10.1016/0002-9378(84)90714-2
article 1980
Heritable aspects of endometriosis
American Journal of Obstetrics and Gynecology ·doi:10.1016/0002-9378(80)90917-5
article 1980
Heritable aspects of endometriosis
·doi:10.1016/0002-9378(80)90918-7
article 1980
Heritage aspects of endometriosis. II. Clinical characteristics of familial endometriosis.
American Journal of Obstetrics and Gynecology

Clinical characteristics of patients with histologically confirmed pelvic endometriosis who had an affected first-degree relative (N = 18) were compared to those who had no such affected relative (N = 105). The only significant difference w…