Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis

M G Rocha, Valéria A. Gomes, V A Gomes, José E. Tanus‐Santos, J E Tanus-Santos, J C Rosa-e-Silva, Júlio César Rosa e Silva, F J Candido-dos-Reis, Francisco José Cândido dos Reis, Antônio Alberto Nogueira, A A Nogueira, Omero Benedicto Poli‐Neto, O B Poli-Neto
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2015 · vol. 48(4) , pp. 363–369 · doi:10.1590/1414-431x20143619 · PMID:25714893 · W2025288650
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Abstract

The objective of this prospective study was to determine the plasma levels of nitric oxide (NO) in women with chronic pelvic pain secondary to endometriosis (n=24) and abdominal myofascial pain syndrome (n=16). NO levels were measured in plasma collected before and 1 month after treatment. Pretreatment NO levels (μM) were lower in healthy volunteers (47.0±12.7) than in women with myofascial pain (64.2±5.0, P=0.01) or endometriosis (99.5±12.9, P<0.0001). After treatment, plasma NO levels were reduced only in the endometriosis group (99.5±12.9 vs 61.6±5.9, P=0.002). A correlation between reduction of pain intensity and reduction of NO level was observed in the endometriosis group [correlation = 0.67 (95%CI = 0.35 to 0.85), P<0.0001]. Reduction of NO levels was associated with an increase of pain threshold in this group [correlation = -0.53 (-0.78 to -0.14), P<0.0001]. NO levels appeared elevated in women with chronic pelvic pain diagnosed as secondary to endometriosis, and were directly associated with reduction in pain intensity and increase in pain threshold after treatment. Further studies are needed to investigate the role of NO in the pathophysiology of pain in women with endometriosis and its eventual association with central sensitization.

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Condition tags

mesh:D004715mesh:D017699endometriosischronic_pelvic_pain

MeSH descriptors

Chronic Pain Endometriosis Nitric Oxide Pain Threshold Pelvic Pain Adult Chronic Pain Chronic Pain Endometriosis Endometriosis Female Humans Laparoscopy Myofascial Pain Syndromes Myofascial Pain Syndromes Nitric Oxide Pain Measurement Pain Threshold Pelvic Pain Pelvic Pain

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SciLite annotations

chemicals 18
nitric oxide nitric oxide nitric oxide carbon dioxide lidocaine salt nitrate nitrite nitrate nitrate potassium dihydrogen phosphate nitrate phosphoric acid phenylenediamine nitrate prostaglandin prostaglandin arginine
organisms 7
multicellular animals humans noordeloos 2009062 noordeloos 2009062 noordeloos 2009062 noordeloos 2009062 noordeloos 2009062

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