CD33+CD14+CD11b+HLA‐DR− monocytic myeloid‐derived suppressor cells recruited and activated by CCR9/CCL25 are crucial for the pathogenic progression of endometriosis

Ya Nan Sun, Ya Sun, Jun Shao, Feizhou Jiang, Yanqiu Wang, Qin Yan, Yan Qin, Na Yu, Jin Zhang, Jie Zhang, Mingqing Li, Ming‐Qing Li, Yinyan He
American journal of reproductive immunology (New York, N.Y. : 1989) · 2018 · vol. 81(1) , pp. e13067 · doi:10.1111/aji.13067 · PMID:30375700 · W2898631296
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Abstract

PROBLEM: Endometriosis (EM) is a chronic immunoinflammatory disease associated with an abnormal immunotolerant microenvironment. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that play a major role in immunosuppression in cancer, inflammation and other diseases. This paper aims to elucidate whether or not MDSCs are involved in regulating this microenvironment in EM and how this regulation occurs. METHOD OF STUDY: T cells stimulated with α-CD3/α-CD28 antibody. After 72 hours of co-culture, proliferation was measured to rate the immunosuppressive function of M-MDSCs. Finally, levels of IL-10, GM-CSF and arginase activity in the cultured supernatants were detected. RESULTS: M-MDSCs. CONCLUSION: M-MDSCs recruited and activated by CCR9/CCL25 play a crucial role in the pathogenic progression of endometriosis, thus providing a potential target for EM treatment.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

CD11b Antigen CD8-Positive T-Lymphocytes Chemokines, CC Endometriosis Myeloid-Derived Suppressor Cells Adult CD11b Antigen CD11b Antigen CD8-Positive T-Lymphocytes Cell Differentiation Cell Proliferation Cells, Cultured Cellular Microenvironment Chemokines, CC Chemokines, CC Chemotaxis Disease Progression Endometriosis Female HLA-DR Antigens

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