Serum and peritoneal fluid levels of IGF I and II and insulinlike growth binding protein-3 in endometriosis.
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This study found that serum and peritoneal fluid levels of IGF I, IGF II, and IGFBP 3 differ between endometriosis patients and controls, with higher serum IGF I correlating with late-stage endometriosis.
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Abstract
OBJECTIVE: To examine whether insulinlike growth factor I (IGF I), IGF II and IGF binding protein 3 (IGFBP 3) in serum and peritoneal fluid (PF) correlate with the presence and severity of endometriosis. STUDY DESIGN: Case-control study including 29 patients with endometriosis and 15 controls. The revised American Fertility Society classification stages of I and II were pooled as early-stage (n = 15), and stages III and IV were taken as late stage (n = 14). Simultaneous sampling of blood and PF was performed during laparoscopy, and IGF I, IGF II and IGFBP 3 levels were determined by immunoradiometric assay. RESULTS: The serum levels of all three proteins were higher than PF levels except for a reversed IGF I PF: serum ratio in the early stage. There were no significant differences in IGF II and IGFBP 3 levels among the groups. The mean serum IGF I levels of controls and early-stage patients were significantly lower than those in the late stage. Also, mean PF IGF I levels in controls were significantly lower than in the late stage. CONCLUSION: IGF I may be an important mediator in the development and/or maintenance of endometriosis or progression to late-stage disease.
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Cited by (29)
- MiR-19b-3p inhibits cell viability and proliferation and promotes apoptosis by targeting IGF1 in KGN cells 2023
- Differential Expression of Insulin Growth Factor 1 (IGF-1) Isoforms in Different Types of Endometriosis: Preliminary Results of a Single-Center Study 2023
- Endometriosis Research: From Bench to Bedside 2022
- Expression levels of MCP-1, HGF, and IGF-1 in endometriotic patients compared with non-endometriotic controls 2021
- Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives 2020
- Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies 2018
- Epidemiological and Clinical Risk Factors for Endometriosis 2017
- Associations among body size across the life course, adult height and endometriosis 2017
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- A Prospective Study of Insulin-Like Growth Factor 1, Its Binding Protein 3, and Risk of Endometriosis 2015
- Current Insights and Future Advances in Endometriosis Diagnostics 2012
- The emerging role of epigenetics in the aetiology of endometriosis. 2011
- A prospective study of body size during childhood and early adulthood and the incidence of endometriosis 2010
- Deregulation of LOXL1 and HTRA1 Gene Expression in Endometriosis 2010
- Peripheral biomarkers of endometriosis: a systematic review 2010
- Cytokine and immune cell levels in peritoneal fluid and peripheral blood of women with early- and late-staged endometriosis 2008
- Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? 2006
- Endometriosis: harmful survival of an ectopic tissue 2006
- Serum and endometrial markers 2004
- Serum Concentrations of Insulin‐like Growth Factor‐1, Soluble Tumor Necrosis Factor Receptor‐1 and Angiogenin in Endometriosis Patients 2004
- Concentrations of Alpha-Fetoprotein, Insulin-Like Growth Factor Binding Protein-3, c-erbB-2, and Epidermal Growth Factor in Serum of Patients With Endometriosis 2004
- In utero exposures and the incidence of endometriosis 2004
- Levels of vascular endothelial growth factor (VEGF) in serum of patients with endometriosis 2003
- Angiogenic Factors in Endometriosis 2002
- Spatially Heterogenous Expression of Aromatase P450 through Promoter II Is Closely Correlated with the Level of Steroidogenic Factor-1 Transcript in Endometrioma Tissues 2002
- IGF-1 in gynaecology and obstetrics: update 2002 2002
- Spatially Heterogenous Expression of Aromatase P450 through Promoter II Is Closely Correlated with the Level of Steroidogenic Factor-1 Transcript in Endometrioma Tissues 2002
- Angiogenesis in Endometriosis 2001
- Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis 2000
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