Nerve Bundles and Deep Dyspareunia in Endometriosis

Christina Williams, Lien Hoang, Ali Yosef, Fahad Alotaibi, Fahad T. Alotaibi, Catherine Allaire, Lori A. Brotto, Lori Brotto, Ian S Fraser, Mohamed A Bedaiwy, Tony Ng, Tony L Ng, Anna F Lee, Paul J Yong
Reproductive sciences (Thousand Oaks, Calif.) · 2015 · vol. 23(7) , pp. 892–901 · doi:10.1177/1933719115623644 · PMID:26711313 · W2412658806
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This immunohistochemistry study found significantly higher nerve bundle density in the cul-de-sac/uterosacrals of endometriosis patients with deep dyspareunia compared to controls.

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- Library Home / - Search Collections / - Open Collections / - Browse Collections / - UBC Faculty Research and Publications / - Nerve bundles and deep dyspareunia in endometriosis Open Collections UBC Faculty Research and Publications Nerve bundles and deep dyspareunia in endometriosis Williams, Christina; Hoang, Lien N.; Yosef, Ali; Fahad, Alotaibi; Allaire, Catherine; Brotto, Lori A.; Fraser, Ian S.; Bedaiwy, Mohamed Ali, 1968-; Ng, Tony Ling Tin; Lee, Anna F.; Yong, Paul J. Abstract The etiology of deep dyspareunia in endometriosis is unclear. Our objective was to determine whether nerve bundle density in the cul-de-sac/uterosacrals (Zone II) is associated with deep dyspareunia in women with endometriosis. We conducted a blinded retrospective immunohistochemistry study (n=58) at a tertiary referral center (2011-2013). Patients were stringently phenotyped into a Study Group and two Control Groups. The Study Group (tender endometriosis, n=29) consisted of patients with deep dyspareunia, a tender Zone II on examination, and an endometriosis lesion in Zone II excised at surgery. Control Group 1 (nontender endometriosis, n=17) consisted of patients without deep dyspareunia, a non-tender Zone II on examination, and an endometriosis lesion in Zone II excised at surgery. Control Group 2 (tender non-endometriosis, n=12) consisted of patients with deep dyspareunia, a tender Zone II on examination, and a non-endometriosis lesion (e.g. normal histology) in Zone II excised at surgery. PGP9.5 immunohistochemistry was performed to identify nerve bundles (nerve fibers surrounded by perineurium) in the excised Zone II lesion. PGP9.5 nerve bundle density (bundles/HPF) was then scored by a pathologist blinded to the Group. We found a significant difference in PGP9.5 nerve bundle density between the three Groups (ANOVA, F[2,55]=6.39, p=0.003). Mean PGP9.5 nerve bundle density was significantly higher in the Study Group (1.16+/-0.56 bundles/HPF [+/-SD]), compared to Control Group 1 (0.65+/-0.36, Tukey test, p=0.005) and Control Group 2 (0.72+/-0.56, Tukey test, p=0.044). This study provides evidence that neurogenesis in the cul-de-sac/uterosacrals may be an etiological factor for deep dyspareunia in endometriosis. Item Metadata | Title | Nerve bundles and deep dyspareunia in endometriosis | | Creator | | | Date Issued | 2015 | | Description | The etiology of deep dyspareunia in endometriosis is unclear. Our objective was to determine whether nerve bundle density in the cul-de-sac/uterosacrals (Zone II) is associated with deep dyspareunia in women with endometriosis. We conducted a blinded retrospective immunohistochemistry study (n=58) at a tertiary referral center (2011-2013). Patients were stringently phenotyped into a Study Group and two Control Groups. The Study Group (tender endometriosis, n=29) consisted of patients with deep dyspareunia, a tender Zone II on examination, and an endometriosis lesion in Zone II excised at surgery. Control Group 1 (nontender endometriosis, n=17) consisted of patients without deep dyspareunia, a non-tender Zone II on examination, and an endometriosis lesion in Zone II excised at surgery. Control Group 2 (tender non-endometriosis, n=12) consisted of patients with deep dyspareunia, a tender Zone II on examination, and a non-endometriosis lesion (e.g. normal histology) in Zone II excised at surgery. PGP9.5 immunohistochemistry was performed to identify nerve bundles (nerve fibers surrounded by perineurium) in the excised Zone II lesion. PGP9.5 nerve bundle density (bundles/HPF) was then scored by a pathologist blinded to the Group. We found a significant difference in PGP9.5 nerve bundle density between the three Groups (ANOVA, F[2,55]=6.39, p=0.003). Mean PGP9.5 nerve bundle density was significantly higher in the Study Group (1.16+/-0.56 bundles/HPF [+/-SD]), compared to Control Group 1 (0.65+/-0.36, Tukey test, p=0.005) and Control Group 2 (0.72+/-0.56, Tukey test, p=0.044). This study provides evidence that neurogenesis in the cul-de-sac/uterosacrals may be an etiological factor for deep dyspareunia in endometriosis. | | Subject | | | Genre | | | Type | | | Language | eng | | Date Available | 2017-02-01 | | Provider | Vancouver : University of British Columbia Library | | Rights | Attribution-NonCommercial-NoDerivatives 4.0 International | | DOI | 10.14288/1.0303148 | | URI | | | Affiliation | | | Citation | Williams, C., Hoang, L., Yosef, A., Alotaibi, F., Allaire, C., Brotto, L., . . . Yong, P. J. (2015). Nerve bundles and deep dyspareunia in endometriosis. Reproductive Sciences, | | Publisher DOI | 10.1177/1933719115623644 | | Peer Review Status | Reviewed | | Scholarly Level | Faculty | | Copyright Holder | SAGE | | Rights URI | | | Aggregated Source Repository | DSpace | Item Media Item Citations and Data Rights Attribution-NonCommercial-NoDerivatives 4.0 International

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Condition tags

mesh:D004414mesh:D004715mesh:D017699endometriosisdyspareunia

MeSH descriptors

Dyspareunia Dyspareunia Endometriosis Nerve Fibers Uterus Adolescent Adult Dyspareunia Dyspareunia Endometriosis Female Humans Middle Aged Nerve Fibers Nerve Fibers Pelvic Pain Pelvic Pain Retrospective Studies Ubiquitin Thiolesterase Ubiquitin Thiolesterase

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