Endometriosis and adenomyosis unveiled through single-cell glasses

Linda C Giudice; Bi‐Cheng Liu; Binya Liu; Juan C Irwin

doi:10.1016/j.ajog.2024.08.043

Endometriosis and adenomyosis unveiled through single-cell glasses

Linda C Giudice, Bi‐Cheng Liu, Binya Liu, Juan C Irwin

American journal of obstetrics and gynecology · 2025 · vol. 232(4) , pp. S105–S123 · doi:10.1016/j.ajog.2024.08.043 · PMID:40253075 · W4409535916

review OA: closed CC0 ⤵ 2 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper uses single-cell RNA sequencing to analyze the cellular composition and molecular profiles of endometriosis and adenomyosis tissues, aiming to identify key cell types and pathways involved in their pathogenesis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

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Outcome instruments

rASRM

Condition tags

mesh:D004715endometriosisadenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (98)

Adenomyosis: Current knowledge, Recent Advances and Future Perspective via openalex
Adenomyosis: Mechanisms and Pathogenesis via openalex
Adenomyosis pathogenesis: insights from next-generation sequencing via openalex
A molecular staging model for accurately dating the endometrial biopsy via openalex
Biobanking human endometrial tissue and blood specimens: standard operating procedure and importance to reproductive biology research and diagnostic development via openalex
Cancer-Associated Mutations in Endometriosis without Cancer via openalex
Comparing gene expression in deep infiltrating endometriosis with adenomyosis uteri: evidence for dysregulation of oncogene pathways via openalex
Current and Future Medical Therapies for Adenomyosis via openalex
Current and Future Surgical and Interventional Management Options for Adenomyosis via openalex
Decreased expression of killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with adenomyosis via openalex
Does endometriosis affect professional life? A matched case-control study in Switzerland, Germany and Austria via openalex
Endometrial microbiota in women with and without adenomyosis: A pilot study via openalex
Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions via openalex
ENDOMETRIAL SUBCELLULAR ALTERATIONS IN ENDOMETRIOSIS IDENTIFIED BY SINGLE-CELL ANALYSIS ACROSS THE MENSTRUAL CYCLE via openalex
Endometriosis via openalex
Endometriosis via openalex
Endometriosis: recent advances that could accelerate diagnosis and improve care via openalex
Epidemiology of Adenomyosis via openalex
Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility via openalex
Experience of Symptoms and Disease Impact in Patients with Adenomyosis via openalex
Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis via openalex
Gut Microbiome–Estrobolome Profile in Reproductive-Age Women with Endometriosis via openalex
Gut microbiota and microbiota-derived metabolites promotes endometriosis via openalex
Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis1 via openalex
Imaging Diagnosis of Adenomyosis via openalex
Immunological changes associated with adenomyosis: a systematic review via openalex
Impaired decidualization of human endometrial stromal cells from women with adenomyosis† via openalex
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro via openalex
Mechanisms and Pathogenesis of Adenomyosis via openalex
Psychosocial impact of endometriosis: From co-morbidity to intervention via openalex
Quality of life in women with endometriosis: a narrative overview via openalex
Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis via openalex
Single-cell transcriptome analysis reveals endometrial immune microenvironment in minimal/mild endometriosis via openalex
Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity via openalex
Single-cell transcriptomic analysis of eutopic endometrium and ectopic lesions of adenomyosis via openalex
Stromal Heterogeneity in the Human Proliferative Endometrium—A Single-Cell RNA Sequencing Study via openalex
Symptoms of Adenomyosis and Overlapping Diseases via openalex
The bidirectional relationship between endometriosis and microbiome via openalex
The cyclic pattern of the immunocytochemical expression of oestrogen and progesterone receptors in human myometrial and endometrial layers: characterization of the endometrialsubendometrial unit via openalex
The endometrial immune environment of women with endometriosis via openalex
The endometrial–myometrial junction: a fresh look at a busy crossing via openalex
The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain via openalex
The role of the B lymphocytes in endometriosis: A systematic review via openalex
The social and psychological impact of endometriosis on women's lives: a critical narrative review via openalex
The study of endometriosis and adenomyosis related microbiota in female lower genital tract in Northern Chinese population via openalex
Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis via openalex
Using advanced spatial and single-cell transcriptomics to characterize the human endometrium via openalex
Uterine junctional zone: function and disease via openalex
Vaginal microbiome of women with adenomyosis: A case-control study via openalex
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Cited by (2)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pmc: last seen: 2026-05-13T20:22:03.195721+00:00
pubmed: last seen: 2026-06-04T00:31:40.118107+00:00
unpaywall: last seen: 2026-06-02T02:00:03.124865+00:00

License: CC0 · commercial use OK

[1] Adenomyosis: Current knowledge, Recent Advances and Future Perspective via openalex

[2] Adenomyosis: Mechanisms and Pathogenesis via openalex

[3] Adenomyosis pathogenesis: insights from next-generation sequencing via openalex

[4] A molecular staging model for accurately dating the endometrial biopsy via openalex

[5] Biobanking human endometrial tissue and blood specimens: standard operating procedure and importance to reproductive biology research and diagnostic development via openalex

[6] Cancer-Associated Mutations in Endometriosis without Cancer via openalex

[7] Comparing gene expression in deep infiltrating endometriosis with adenomyosis uteri: evidence for dysregulation of oncogene pathways via openalex

[8] Current and Future Medical Therapies for Adenomyosis via openalex

[9] Current and Future Surgical and Interventional Management Options for Adenomyosis via openalex

[10] Decreased expression of killer cell inhibitory receptors on natural killer cells in eutopic endometrium in women with adenomyosis via openalex

[11] Does endometriosis affect professional life? A matched case-control study in Switzerland, Germany and Austria via openalex

[12] Endometrial microbiota in women with and without adenomyosis: A pilot study via openalex

[13] Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions via openalex

[14] ENDOMETRIAL SUBCELLULAR ALTERATIONS IN ENDOMETRIOSIS IDENTIFIED BY SINGLE-CELL ANALYSIS ACROSS THE MENSTRUAL CYCLE via openalex

[15] Endometriosis via openalex

[16] Endometriosis via openalex

[17] Endometriosis: recent advances that could accelerate diagnosis and improve care via openalex

[18] Epidemiology of Adenomyosis via openalex

[19] Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility via openalex

[20] Experience of Symptoms and Disease Impact in Patients with Adenomyosis via openalex

[21] Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis via openalex

[22] Gut Microbiome–Estrobolome Profile in Reproductive-Age Women with Endometriosis via openalex

[23] Gut microbiota and microbiota-derived metabolites promotes endometriosis via openalex

[24] Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis1 via openalex

[25] Imaging Diagnosis of Adenomyosis via openalex

[26] Immunological changes associated with adenomyosis: a systematic review via openalex

[27] Impaired decidualization of human endometrial stromal cells from women with adenomyosis† via openalex

[28] Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro via openalex

[29] Mechanisms and Pathogenesis of Adenomyosis via openalex

[30] Psychosocial impact of endometriosis: From co-morbidity to intervention via openalex

[31] Quality of life in women with endometriosis: a narrative overview via openalex

[32] Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis via openalex

[33] Single-cell transcriptome analysis reveals endometrial immune microenvironment in minimal/mild endometriosis via openalex

[34] Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity via openalex

[35] Single-cell transcriptomic analysis of eutopic endometrium and ectopic lesions of adenomyosis via openalex

[36] Stromal Heterogeneity in the Human Proliferative Endometrium—A Single-Cell RNA Sequencing Study via openalex

[37] Symptoms of Adenomyosis and Overlapping Diseases via openalex

[38] The bidirectional relationship between endometriosis and microbiome via openalex

[39] The cyclic pattern of the immunocytochemical expression of oestrogen and progesterone receptors in human myometrial and endometrial layers: characterization of the endometrialsubendometrial unit via openalex

[40] The endometrial immune environment of women with endometriosis via openalex

[41] The endometrial–myometrial junction: a fresh look at a busy crossing via openalex

[42] The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain via openalex

[43] The role of the B lymphocytes in endometriosis: A systematic review via openalex

[44] The social and psychological impact of endometriosis on women's lives: a critical narrative review via openalex

[45] The study of endometriosis and adenomyosis related microbiota in female lower genital tract in Northern Chinese population via openalex

[46] Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis via openalex

[47] Using advanced spatial and single-cell transcriptomics to characterize the human endometrium via openalex

[48] Uterine junctional zone: function and disease via openalex

[49] Vaginal microbiome of women with adenomyosis: A case-control study via openalex

[50] World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research via openalex

[51] World Endometriosis Research Foundation Endometriosis Phenome and biobanking harmonization project: II. Clinical and covariate phenotype data collection in endometriosis research via openalex

[52] World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research via openalex

[53] W7034376784 via openalex

[54] W2026056052 via openalex

[55] W2030284622 via openalex

[56] W2121381144 via openalex

[57] W2159922867 via openalex

[58] W2164002837 via openalex

[59] W2469348810 via openalex

[60] W2477008945 via openalex

[61] W2513121273 via openalex

[62] W2570519144 via openalex

[63] W2965589450 via openalex

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[67] W3086909323 via openalex

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