Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signalling-An Introduction

Denker H; Denker HW; Dimitriadis E; Evdokia Dimitriadis; Lois A. Salamonsen; Salamonsen L

doi:10.3390/biom16060921

Embryo Implantation: New Molecular Insights in Endometrial Receptivity, Trophoblast Invasion and Signalling-An Introduction

Denker H, Denker HW, Dimitriadis E, Evdokia Dimitriadis, Lois A. Salamonsen, Salamonsen L

Biomolecules · 2026 · vol. 16(6) · doi:10.3390/biom16060921 · PMID:42352387 · PMC13296509

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This introductory paper provides new molecular insights into endometrial receptivity, trophoblast invasion, and signaling mechanisms relevant to embryo implantation.

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This introductory article outlines recent molecular advancements in understanding embryo implantation, specifically focusing on endometrial receptivity, trophoblast invasion, and cellular signaling pathways. It synthesizes findings from multiple contemporary studies that utilize advanced three-dimensional uterine models, stem cell-based systems, and omics technologies to dissect the complex interactions at the maternal-fetal interface. The text highlights how changes in epithelial cell polarity and adhesion molecules guide human endometrial receptivity while also examining the role of blastocyst-derived lactate and HOX gene expression in reproductive health. Relevance to endometriosis: The paper is not centrally about endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Embryo implantation within the uterus is critical for the establishment of pregnancy and is an important issue in infertility [...].

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List

Denker, H.-W.; Back to the Future-A 50-Year Dive into Embryo Implantation Research: Cell Biological Paradox, Epithelial Cell Polarity, and EMT. Biomolecules 2026 , 16 , 293. https://doi.org/10.3390/biom16020293 . Classen-Linke, I.; Buck, V.U.; Sternberg, A.K.; Kohlen, M.; Izmaylova, L.; Leube, R.E. Changes in epithelial cell polarity and adhesion guide human endometrial receptivity: How in vitro systems help to untangle mechanistic details. Biomolecules 2025 , 15 , 1057. https://doi.org/10.3390/biom15081057 . Douglas, J.A.; Higgins, J.; Wimalasiri, D.H.; Winship, A.L.; Fitzgerald, H.C. Engineering the human endometrial-embryo interface: Breakthroughs in 3D uterine models. Biomolecules 2026 , 16 , 383. https://doi.org/10.3390/biom16030383 . Munsie, M.; Findlay, J.K. Three-Dimensional Models of Implantation Using Human Stem Cells: Scientific Insights and Broader Considerations. Biomolecules 2025 , 15 , 1023. https://doi.org/10.3390/biom15071023 . Holm, S. Human Stem Cell-Based Embryo Models in Implantation Research: Regulation, Consistency and Potential. Biomolecules 2025 , 15 , 1287. https://doi.org/10.3390/biom15091287 . Li, S.Y.; DeMayo, F.J. Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies. Biomolecules 2025 , 15 , 450. https://doi.org/10.3390/biom15030450 . Ye, L.; Dimitriadis, E. Endometrial Receptivity-Lessons from “Omics”. Biomolecules 2025 , 15 , 106. https://doi.org/10.3390/biom15010106 . Pîrlog, L.M.; Pătrășcanu, A.-A.; Ona, M.-D.; Cătană, A.; Rotar, I.C. HOXA10 and HOXA11 in Human Endometrial Benign Disorders: Unraveling Molecular Pathways and Their Impact on Reproduction. Biomolecules 2025 , 15 , 563. https://doi.org/10.3390/biom15040563 . Gurner, K.H.; Gardner, D.K. Blastocyst-Derived Lactate as a Key Facilitator of Implantation. Biomolecules 2025 , 15 , 100. https://doi.org/10.3390/biom15010100 . Johnson, G.A.; Minela, T.; Seo, H.; Bazer, F.W.; Burghardt, R.C.; Wu, G.; Pohler, K.G.; Stenhouse, C.; Cain, J.W.; Seekford, Z.K.; et al. Conceptus elongation, implantation, and early placental development in species with central implantation: Pigs, sheep, and cows. Biomolecules 2025 , 15 , 1037. https://doi.org/10.3390/biom15071037 .

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Conflicts

The authors declare no conflicts of interest.

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MeSH descriptors

Embryo Implantation Endometrium Endometrium Endometrium Trophoblasts Trophoblasts Trophoblasts Trophoblasts Animals Female Humans Pregnancy Signal Transduction

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europepmc: last seen: 2026-10-18T09:30:06.152893+00:00
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