{"paper_id":"12ef594e-99ea-4e13-b698-3cc8c9c2cfd3","body_text":"The authors declare no conflicts of interest.\n\nDenker, H.-W.; Back to the Future-A 50-Year Dive into Embryo Implantation Research: Cell Biological Paradox, Epithelial Cell Polarity, and EMT.  Biomolecules \n 2026 ,  16 , 293.  https://doi.org/10.3390/biom16020293 .\nClassen-Linke, I.; Buck, V.U.; Sternberg, A.K.; Kohlen, M.; Izmaylova, L.; Leube, R.E. Changes in epithelial cell polarity and adhesion guide human endometrial receptivity: How in vitro systems help to untangle mechanistic details.  Biomolecules \n 2025 ,  15 , 1057.  https://doi.org/10.3390/biom15081057 .\nDouglas, J.A.; Higgins, J.; Wimalasiri, D.H.; Winship, A.L.; Fitzgerald, H.C. Engineering the human endometrial-embryo interface: Breakthroughs in 3D uterine models.  Biomolecules \n 2026 ,  16 , 383.  https://doi.org/10.3390/biom16030383 .\nMunsie, M.; Findlay, J.K. Three-Dimensional Models of Implantation Using Human Stem Cells: Scientific Insights and Broader Considerations.  Biomolecules \n 2025 ,  15 , 1023.  https://doi.org/10.3390/biom15071023 .\nHolm, S. Human Stem Cell-Based Embryo Models in Implantation Research: Regulation, Consistency and Potential.  Biomolecules \n 2025 ,  15 , 1287.  https://doi.org/10.3390/biom15091287 .\nLi, S.Y.; DeMayo, F.J. Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies.  Biomolecules \n 2025 ,  15 , 450.  https://doi.org/10.3390/biom15030450 .\nYe, L.; Dimitriadis, E. Endometrial Receptivity-Lessons from “Omics”.  Biomolecules \n 2025 ,  15 , 106.  https://doi.org/10.3390/biom15010106 .\nPîrlog, L.M.; Pătrășcanu, A.-A.; Ona, M.-D.; Cătană, A.; Rotar, I.C. HOXA10 and HOXA11 in Human Endometrial Benign Disorders: Unraveling Molecular Pathways and Their Impact on Reproduction.  Biomolecules \n 2025 ,  15 , 563.  https://doi.org/10.3390/biom15040563 .\nGurner, K.H.; Gardner, D.K. Blastocyst-Derived Lactate as a Key Facilitator of Implantation.  Biomolecules \n 2025 ,  15 , 100.  https://doi.org/10.3390/biom15010100 .\nJohnson, G.A.; Minela, T.; Seo, H.; Bazer, F.W.; Burghardt, R.C.; Wu, G.; Pohler, K.G.; Stenhouse, C.; Cain, J.W.; Seekford, Z.K.; et al. Conceptus elongation, implantation, and early placental development in species with central implantation: Pigs, sheep, and cows.  Biomolecules \n 2025 ,  15 , 1037.  https://doi.org/10.3390/biom15071037 .\n\nDisclaimer/Publisher’s Note:  The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.","source_license":"CC-BY-4.0","license_restricted":false}