Correlation Between Altered Central Pain Processing and Concentration of Peritoneal Fluid Inflammatory Cytokines in Endometriosis Patients With Chronic Pelvic Pain

Alban Y Neziri, Nick A Bersinger, Ole K Andersen, Ole Kæseler Andersen, Lars Arendt‐Nielsen, Lars Arendt-Nielsen, Michael D Mueller, Michele Curatolo
Regional anesthesia and pain medicine · 2014 · vol. 39(3) , pp. 181–184 · doi:10.1097/aap.0000000000000068 · PMID:24694998 · W1999351147
article OA: bronze CC0 ⤵ 17 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Endometriosis patients with chronic pain showed correlations between peritoneal fluid inflammatory cytokines and amplified central pain processing, suggesting cytokines may mediate peripheral inflammation's central effects.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Translational research has not yet elucidated whether alterations in central pain processes are related to peripheral inflammatory processes in chronic pain patients. We tested the hypothesis that the concentration of cytokines in the peritoneal fluid of endometriosis patients with chronic pain correlate with parameters of hyperexcitability of the nociceptive system. The concentrations of 15 peritoneal fluid cytokines were measured in 11 patients with chronic pelvic pain and a diagnosis of endometriosis. Six parameters assessing central pain processes were recorded. Positive correlations between concentration of some cytokines in the peritoneal fluid and amplification of central pain processing were found. The results suggest that inflammatory mechanisms may be important in the pathophysiology of altered central pain processes and that cytokines produced in the environment of endometriosis could act as mediators between the peripheral lesion and changes in central nociceptive processes.

My notes (saved in your browser only)

Condition tags

mesh:D004715mesh:D017699endometriosischronic_pelvic_pain

MeSH descriptors

Ascitic Fluid Chronic Pain Cytokines Endometriosis Pain Pelvic Pain Adolescent Adult Ascitic Fluid Chronic Pain Chronic Pain Cytokines Endometriosis Endometriosis Female Humans Nociception Pain Pelvic Pain Pelvic Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (1)

Cited by (17)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:18:35.150238+00:00
License: CC0 · commercial use OK