Histomorphological changes in endometriosis in a patient treated with ulipristal: A case report
Case report
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This case report details the histomorphological changes observed in endometriosis after treatment with ulipristal acetate.
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Abstract
BACKGROUND: Selective progesterone receptor modulators have shown efficacy in the treatment of endometriosis, however they are not currently licensed in Canada for this purpose. Their histomorphological effects have been well documented in the endometrium, but not in endometriosis.
CASE REPORT: The patient presented with uterine fibroids and heavy menstrual bleeding, and was treated with ulipristal acetate over three 90-day courses. She eventually elected to undergo definitive surgical management. On pathological examination, she was found to have a focus of endometriosis in the para-tubal soft tissue showing a morphology similar to progesterone receptor modulator associated endometrial changes (PAEC).
CONCLUSIONS: To our knowledge this is the first reported case of PAEC involving a focus of endometriosis. This case demonstrates histomorphological evidence of the effects of ulipristal acetate on endometriosis, and thus provides evidence of a pharmacological effect.
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References (10)
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Cited by (7)
- Effects of Ulipristal Acetate on Reactive Oxygen Species and Proinflammatory Cytokine Release by Epithelial and Stromal Cells from Human Endometrium and Endometriosis 2023
- Approach to Pain in Endometriosis Patients: Systematic Literature Review 2022
- Ulipristal Acetate Prior to Surgery for Endometriosis 2020
- Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure 2020
- HORMONAL THERAPY IN WOMEN OF REPRODUCTIVE AGE WITH ENDOMETRIOSIS: AN UPDATE 2019
- Endometrial Changes in Surgical Specimens of Perimenopausal Patients Treated With Ulipristal Acetate for Uterine Leiomyomas 2017
- [Medical treatment of endometriosis: Hormonal treatment of pain, impact on evolution and future perspectives] 2017
Source provenance
- europepmc
- last seen: 2026-10-25T09:32:14.900964+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:18:58.561258+00:00
- unpaywall
- last seen: 2026-10-25T06:24:14.523685+00:00
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