A preliminary immunopharmacological study of an antiendometriotic herbal medicine, Keishi-bukuryo-gan.

T Tanaka, Tetsuji Tanaka, K Mizuno, Kuniko Mizuno, N Umesaki, Naohiko Umesaki, Sachio Ogita, S Ogita
Osaka city medical journal · 1998 · vol. 44(1) , pp. 117–24 · PMID:9834624 · W2184360317
article OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Keishi-bukuryo-gan decreased specific antiendometrial IgM antibody titers and maintained symptom-free status in an endometriosis patient, unlike leuproride acetate.

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Abstract

Changes in the specific antiendometrial IgM antibodies in an endometriotic patient, who were treated with leuproride acetate and in turn with Keishi-bukuyogan, were investigated by the flowcytometric analysis which was developed in our laboratory. The oriental therapy decreased the specific IgM antibody titer gradually and kept the patient symptom-free for more than 7 months without any suppression of serum CA125 and estradiol levels. On the other hand, leuproride acetate therapy suppressed both serum CA125 and serum estradiol levels but not the IgM antibody titer. The results suggest that the specific antiendometrial IgM autoantibody could be a pathogenic molecule in endometriosis and it could also serve as a clinical marker for the oriental therapy of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Drugs, Chinese Herbal Endometriosis Endometriosis Adult Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Autoantibodies Autoantibodies Cells, Cultured Drugs, Chinese Herbal Endometriosis Female Humans Immunoglobulin M Immunoglobulin M Leuprolide Leuprolide

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

Cited by (5)

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