Reproductive BioMedicine Online

Adenomyosis is characterized by the invasion of endometrial glands and stroma into the myometrium. Its clinical manifestations often include dysmenorrhoea, excessive menstrual bleeding and infertility. Reduced pregnancy and live birth rates…

Adenomyosis, a menstruation-related uterine disorder, refers to the presence of endometrial stroma and glands within the myometrium and is typically observed in reproductive-age women. The pathogenesis explaining the migration, persistence,…

RESEARCH QUESTION: Are pregnancies in female same-sex couples at higher risk when using reception of oocytes from partner (ROPA) compared with intrauterine insemination (IUI)? DESIGN: A retrospective, single-centre, matched cohort study wa…

Endometriosis and endometrial polyps are oestrogen-dependent conditions that frequently co-occur, yet their combined prevalence remains unclear. This study synthesized data on the prevalence of endometrial polyps in women with endometriosis…

RESEARCH QUESTION: Can bioinformatics-driven identification of hub genes in granulosa cells be used to predict oocyte developmental potential in patients with endometriosis (EMS)-related infertility? DESIGN: This was an exploratory cohort …

RESEARCH QUESTION: Do mast cells play a role in the pathogenesis of endometriosis and, if so, what is the mechanism of action? DESIGN: The study included 18 women with ovarian endometriosis and 13 women without endometriosis. Primary endom…

RESEARCH QUESTION: How does tubal endometriosis (TEM) impact the morphology and ultrastructure of tubal epithelium, and what are the underlying pathophysiological mechanisms of TEM? DESIGN: Epithelial samples of fallopian tube were collect…

RESEARCH QUESTION: What is the current time to diagnosis among patients with endometriosis in the Netherlands, and what factors influence this time? DESIGN: A retrospective questionnaire study was conducted in 11 hospitals in the Netherlan…

RESEARCH QUESTION: Does frozen embryo transfer improve pregnancy outcomes compared with fresh embryo transfer in women with ovarian endometriosis (OEM) undergoing their first IVF/intracytoplasmic sperm injection cycle? DESIGN: A retrospect…

RESEARCH QUESTION: Is co-existing polycystic ovarian morphology (PCOM) associated with a higher cumulative live birth rate (LBR) after assisted reproductive technology (ART) in women with advanced endometriosis? DESIGN: A retrospective coh…

RESEARCH QUESTION: What is the relationship between sonographic diagnosis of isolated adenomyosis and placenta-associated obstetric outcomes? DESIGN: In this 12-year retrospective cohort study (2010-2022), patients presenting with adenomyo…

RESEARCH QUESTION: Does the presence of endometriosis and/or adenomyosis, adversely affect oocyte morphology? DESIGN: Retrospective, single-centre study evaluating 29,130 ART cycles between August 2011 and March 2023. Patients diagnosed wi…

Endometriosis poses significant challenges for women of reproductive age, particularly due to its impact on ovarian reserve and fertility. In addition to endometriosis-associated infertility contributing to diminished ovarian reserve by inf…

The aim of this study was to investigate whether gonadotrophin-releasing hormone agonist (GnRHa) pretreatment has a positive effect on pregnancy outcomes in women with adenomyosis who were undergoing a frozen embryo transfer (FET) cycle. A …

This meta-analysis assesses the impact of non-medical endometrioma treatments on pregnancy rates in infertile women with endometriosis. Based on a search of PubMed, Scopus, EMBASE and Web of Science, 24 prospective English-language studies …

A review of advancements in primordial follicle activation and cyclic recruitment research over the past 25 years is presented. The review examines the latest insights into the mechanisms of primordial follicle activation and the role of th…

RESEARCH QUESTION: Is LINC01638 involved in regulation of epithelial-to-mesenchymal transition (EMT) in endometriosis? DESIGN: A prospective patient cohort study was combined with functional experiments in the 12Z endometriosis epithelial …

RESEARCH QUESTION: Could a predictive model, using data from all US fertility clinics reporting to the Society for Assisted Reproductive Technology, estimate the likelihood of patients using their stored oocytes? DESIGN: Multiple learner a…

RESEARCH QUESTION: What is the incidence of endometrioma infections requiring surgical drainage following oocyte retrieval in women with ovarian endometrioma? DESIGN: This retrospective observational cohort study included women aged 18-43 …

RESEARCH QUESTION: What are the lipidomic alterations in the myometrial tissue from adenomyotic lesions? DESIGN: This was a two-centre, prospective, observational study conducted between July 2023 and June 2024. Forty-four premenopausal pa…

RESEARCH QUESTION: Does metformin reverse endometriosis-associated infertility? DESIGN: Endometriosis was induced by transplanting uterus fragments from B6CBAF1 mice into recipients of the same strain. The mice were divided into groups: en…

Couple infertility poses a health challenge, prompting research into its multifaceted aetiology. Non-coding RNA (ncRNA) expression has emerged as a candidate for elucidating couple infertility. This review explores the roles of small and lo…

It is not uncommon that a published paper offers unintended insights, unnoticed by its authors. This was to a substantial degree the case with a recent publication addressing the effects of endometriosis on IVF. Using donor-recipient cycles…