Reproductive BioMedicine Online

Chronic endometritis is persistent inflammation of the endometrium, often underdiagnosed due to its oligosymptomatic presentation. Both chronic endometritis and adenomyosis share inflammatory and structural alterations of the endometrial-my…

RESEARCH QUESTION: Are there differences in lifestyle and environmental exposures, and clinical characteristics between patients with histologically confirmed endometriosis residing in regional and metropolitan locations in Australia, and t…

RESEARCH QUESTION: Is diffuse adenomyosis involving the inner myometrial layer independently associated with chronic endometritis in women with infertility, and women who have experienced recurrent pregnancy loss (RPL) or repeated implantat…

Endometriosis is a chronic, systemic, oestrogen-dependent disease with major impacts on pain, fertility and quality of life. This Society of Endometriosis and Uterine Disorders and American Institute for Minimally Invasive Surgery opinion s…

RESEARCH QUESTION: Do blastocysts vitrified on day 6 result in different clinical outcomes compared with blastocysts vitrified on day 5 in vitrified‒warmed single embryo transfers (SET) without preimplantation genetic testing? DESIGN: A to…

Uterine contractility has emerged as a potential key element in the orchestration of female reproductive functions, with specific motility patterns seemingly aligning with hormonal fluctuations throughout the menstrual cycle. These dynamic …

RESEARCH QUESTION: What is the effect of adenomyosis on cumulative live birth rate (CLBR) in women undergoing single embryo transfer in donor-oocyte cycles, with specific attention to type, location and severity of disease. DESIGN: Retrosp…

RESEARCH QUESTION: What is the impact of focal adenomyosis on IVF/iICSI outcomes, and what is the optimal protocol for these patients? DESIGN: This retrospective study screened 66,711 first IVF/ICSI cycles and identified 598 women with foc…

RESEARCH QUESTION: Does peritoneal iron overload drive fibrosis in endometriosis through Nrf2 pathway dysfunction and the resulting ferroptosis, and can electroacupuncture intervene in this process? DESIGN: An endometriosis mouse model was…

RESEARCH QUESTION: Considering the progressively delayed age of pregnancy, what is the current epidemiology of endometriosis in Japan, including its prevalence, incidence and medication patterns, as revealed by a large-scale, real-world dat…

RESEARCH QUESTION: How can outcomes in programmed frozen embryo transfers (FET) be improved, and what are the key areas where more research is needed? DESIGN: Using a Delphi-consensus framework, a scientific committee comprising five exper…

RESEARCH QUESTION: Can transvaginal ultrasonography (TVUS) reliably detect and quantify free pelvic fluid (FPF) as a surrogate marker of retrograde menstruation, and how do its volume and characteristics vary across menstrual phases, charac…

RESEARCH QUESTION: What is the long-term efficacy of dienogest in treating large ovarian endometriomas (≥5 cm), assessed by transvaginal sonography (TVS) changes in size, greyscale, colour Doppler features, #Enzian score and symptoms over t…

RESEARCH QUESTION: Does pretreatment with a gonadotrophin releasing hormone (GnRH) agonist and an aromatase inhibitor (PRET) improve live birth rates in individuals with endometriosis, adenomyosis, or both, undergoing frozen embryo transfer…

RESEARCH QUESTION: Does adenomyosis increase the risk of thromboembolic events, including both arterial and venous thromboembolism, compared with endometriosis, and what clinical factors may contribute to this association? DESIGN: This ret…

RESEARCH QUESTION: Is endometriosis associated with alterations in the intraovarian steroidogenic milieu in women undergoing IVF compared with rigorously matched women without the disease? DESIGN: Prospective cohort study comparing intrafo…

RESEARCH QUESTION: What is the feasibility of three-dimensional power Doppler ultrasound to predict clinical pregnancy outcome following frozen embryo transfer (FET) in patients with internal adenomyosis (ADM)? DESIGN: This prospective obs…

RESEARCH QUESTION: Is surgery effective in decreasing iron deposition in the ovarian tissue surrounding an ovarian endometrioma? DESIGN: This cohort study was conducted in China between July 2023 and April 2024. Seventy-nine patients with …

RESEARCH QUESTION: Do iron metabolism and ferroptosis influence oocyte and embryo quality in patients with endometriosis undergoing IVF/intracytoplasmic sperm injection (ICSI), or in a mouse model? DESIGN: Fifty-seven patients with laparos…

Endometriomas can be managed through various approaches, including careful observation, medical suppressive therapy, or surgical intervention. Malignancy is rarely a concern in women of reproductive age, making pain relief and the managemen…

This systematic review and meta-analysis (CRD42024588171) compared the effectiveness of surgery followed by IVF/intracytoplasmic sperm injection (IVF/ICSI) with direct IVF/ICSI (i.e. without previous surgery) on the reproductive outcomes of…

RESEARCH QUESTION: Is there a relationship between the location of adenomyosis lesions and obstetric and neonatal outcomes? DESIGN: A total of 466 women diagnosed with adenomyosis via transvaginal ultrasound between January 2019 and Decemb…

RESEARCH QUESTION: Does pyruvate carboxylase drive the progression of endometriosis, and, if so, what is the underlying mechanism? DESIGN: The expression of pyruvate carboxylase in clinical endometrial specimens was examined via immunohist…

RESEARCH QUESTION: Do women with adenomyosis have altered uterine peristalsis, and can an objective and reproducible tool be developed to quantify uterine peristalsis on transvaginal sonography (TVS)? DESIGN: Prospective observational coho…

RESEARCH QUESTION: What are the fertility outcomes in women with endometriosis who attempt to conceive at least 2 years after undergoing fertility preservation. DESIGN: This retrospective, observational, bicentric cohort study included wom…