PloS one

AIMS: The aim of this study was to investigate the mechanism of action of SB on TRP-induced abnormalities of bone metabolism in LNCaP cells. METHODS: The effects of different concentrations of SB and TRP alone and in combination on the pro…

INTRODUCTION: Endometriosis is a prevalent chronic gynecological condition affecting women of reproductive age, characterized by ectopic endometrial-like tissue growth. Despite its significant impact on quality of life, fertility, and healt…

OBJECTIVE: To evaluate whether the COVID-19 pandemic influenced treatment modality, care intensity, and care setting in benign gynecological care in the Netherlands. DESIGN: Retrospective longitudinal cohort study evaluating the effects of…

Endometriosis is a chronic gynecological disorder characterized by persistent pain and impaired quality of life, with limited effective treatment options. Emerging evidence indicates that cannabinoids may provide analgesic and symptom-relie…

BACKGROUND: Cryopreservation and warming can induce cellular stress that impairs oocyte and embryo competence, particularly in poor-prognosis patients. Although fatty acids and melatonin have been proposed to support cytoskeletal stability …

Women with endometriosis and dysmenorrhea are increasingly recognized as having systemic comorbidities beyond pelvic disease, but large-scale data on endocrine and metabolic comorbidities across a broad menstrual-related disorders populatio…

This study explored the genetic evidence linking triglyceride-related pathways and lipid-lowering drug targets with endometriosis risk and investigated the genetic association between TG levels and EM. Using genome-wide association study (G…

BACKGROUND: Endometriosis (EMs) is a chronic inflammatory disease characterized by ectopic endometrial growth. This study aimed to identify and analyze potential signatures of pyroptosis-related genes in EMs. METHODS: We conducted a compre…

INTRODUCTION: The opioid epidemic in the United States poses a major public health challenge, with postoperative prescribing recognized as a significant source of initial opioid exposure. Midwestern states, including Iowa, have experienced …

BACKGROUND: Hysterectomy is a commonly performed gynecologic procedure; however, evidence regarding how different surgical techniques affect postoperative vaginal anatomy and sexual function remains inconsistent. This study aimed to evaluat…

IntroductionIndividuals living with both physical and mental health conditions face compounding barriers to self-management. These challenges arise from complex care needs, interactions between long-term conditions symptoms and inequalities…

OBJECTIVE: To evaluate the efficacy and safety of LED red light therapy in alleviating primary dysmenorrhea. METHODS: A total of 119 patients with primary dysmenorrhea were enrolled in 2022. The intervention was LED red light therapy admin…

BACKGROUND: Persistent autonomic dysfunction disrupts homeostasis and promotes pathological processes underlying several major chronic conditions including cancer and cardiovascular disease. Little is known about the lived experience of ind…

BACKGROUND: Menstruation can be accompanied by stressful experiences and one such experience is the abnormal menstrual cycle, which could include menstrual irregularity and painful menstruation. Menstrual irregularity is defined as deviatio…

BACKGROUND: Gynecological conditions are common among premenopausal women and significantly affect fertility, quality of life, and productivity. Magnetic Resonance Imaging (MRI) offers superior soft tissue characterization compared to other…

A quality improvement project was implemented at a single medical center's outpatient benign gynecological surgery division to address prolonged post anesthesia care unit (PACU) stays (defined as greater than 120 minutes). Initial barrier a…

Non-communicable diseases (NCDs) account for more than 81% of all deaths in Iran and impose a substantial burden on the national health system. Although Iran has implemented multiple initiatives, including the World Health Organization's ST…

Infertility is a global health challenge, and impaired endometrial receptivity remains an important contributor to treatment failure. Endometrial dysbiosis, characterized by a low proportion of Lactobacillus in the endometrial microbiota, h…

BACKGROUND: Vitamin D deficiency is a global public health concern, and women of reproductive age represent a particularly vulnerable population. Accurate measurement of serum 25-hydroxyvitamin D [25(OH)D] is therefore essential for reliabl…

BackgroundRed blood cell volume distribution width (RDW) and albumin have been increasingly recognized for their roles in inflammatory diseases. However, the relationship between RDW-to-albumin ratio (RAR) and acute kidney injury (AKI) in a…

BACKGROUND: Drug-drug interactions (DDIs) represent a major preventable cause of medication-related harm globally. Their prevalence varies across health systems, but common drivers include polypharmacy, aging populations, and specialty-spec…

BACKGROUND: Premenstrual syndrome (PMS) is common among women of reproductive age and may impair quality of life, academic performance, and social functioning. In Lebanon, data on PMS and its management among female university students rema…

This study examined psychophysiological responses to stride frequency manipulation during walking in men and women. Nineteen healthy adults (11 men, 8 women) completed two sessions: familiarization session (session 1) during which the prefe…

Instagram is a social media platform commonly used by parents and caregivers to source complementary feeding advice, yet the reliability of the information provided is unknown. This study aimed to evaluate the quality and accuracy of comple…