Li W

Organoids are rapidly self-organizing 3D in vitro cultures derived from pluripotent stem cells (PSCs) or adult stem cells (ASCs) that possess disease-like characteristics with high success rates. Due to their ability to retain tissue struct…

Uterine fibroids are common among women of reproductive age and often recur after treatment. Accurate recurrence prediction is essential for guiding clinical decisions, yet existing models remain inadequate. This study aimed to develop a no…

OBJECTIVE: Accurately predicting metastatic cancer to the adnexa, stage I and advanced ovarian cancer before surgery is crucial. The ADNEX model, based on ultrasound, is currently the only prediction model that can differentiate between the…

Endometriosis (EMs), a significant global health issue, characterized by unclear pathogenesis, nonspecific symptoms, and poor treatment outcomes. The organ-on-chip technology has achieved great advances in disease modeling, yet its potentia…

INTRODUCTION: Thin endometrium poses a major therapeutic challenge in assisted reproductive technologies by compromising pregnancy success and live birth outcomes. A substantial proportion of patients remain refractory to existing therapies…

BACKGROUND AND OBJECTIVE: Primary dysmenorrhea carries substantial medical, social, and economic burdens, leading many patients to seek low-risk complementary and alternative therapies, such as acupuncture. Myofascial trigger point dry need…

Killer-cell immunoglobulin-like receptor 2DL4 (KIR2DL4), a member of the killer cell immunoglobulin-like receptors (KIRs) family, plays an important role in the regulation of the immune system, which is expressed primarily on natural killer…

OBJECTIVE: To evaluate the pregnancy and perinatal outcomes of different phenotypes of polycystic ovary syndrome (PCOS) patients during the frozen embryo transfer (FET) cycles. Additionally, to analyze the T cell balance in the endometrium …

BACKGROUND: Polycystic ovary syndrome (PCOS) has been extensively studied as a common female endocrine disease. In recent years, the relationship between circadian rhythm and PCOS has gradually drawn attention, although the precise nature o…

BACKGROUND: Endometriosis is a prevalent gynecological disorder that is estimated to affect approximately 10% of women of childbearing age globally. However, the condition remains significantly under-or misrecognized, and the mean time to d…

Ovarian cancer (OC) is a deadly disease and lacks a precise marker for diagnosis worldwide. Our previous work has shown the overexpression of flotillin-1 (FLOT1) in OC tissue. To improve diagnostic sensitivity and accuracy, we evaluated the…

In this single-center, double-blinded, randomized controlled trial, we investigated whether human umbilical cord-derived mesenchymal stromal cells loaded collagen scaffolds (hUC-MSC/CS) could improve the cumulative live-birth rate (cLBR) in…

Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, largely due to its late-stage diagnosis and high recurrence rates. Chronic inflammation is a critical driver of OC progression, contributing to immune evasion, t…

Intravenous leiomyomatosis (IVL) is a rare subtype of benign smooth muscle tumor that can exhibit malignant-like biological behavior. Originating in the uterus, IVL grows in mass-like formations within small veins and can extend into the in…

Atherosclerosis has an urgent need for new therapeutic targets. Protein kinases orchestrate multiple cellular events in atherosclerosis and may provide new therapeutic targets for atherosclerosis. Here, a protein kinase, WEE1 G2 checkpoint …

Retrograde menstruation is a widely recognized etiological factor for endometriosis (EMs); however, it is not the sole cause, as not all affected women develop EMs. Emerging evidence suggests a significant association between the vaginal mi…

MicroRNAs (miRNAs) are a class of non-coding RNA. MiRNAs affect physiological processes by regulating messenger RNA (mRNA) translation of target genes. The peri-implantation period is the period with the most loss of pig embryos, during whi…

Colorectal cancer (CRC) is a common malignancy, and TRIM24, an E3 ubiquitin ligase, is a potential target for various cancers. This study found high TRIM24 expression in CRC, correlating with poor prognosis and disease progression. Oroxin A…

Nanodrug delivery systems (NDDS) have demonstrated broad application prospects in disease treatment, prevention, and diagnosis due to several advantages, including functionalization capability, high drug-loading capacity, drug stability pro…

OBJECTIVE: To study if the transfer of warmed blastocysts without blastocoele re-expansion is effective and safe. METHODS: Three thousand one hundred ninety-six frozen-thawed single blastocyst transfer cycles were conducted. The embryos we…

RESEARCH QUESTION: Does preimplantation genetic testing for aneuploidy (PGT-A) on cryopreserved unbiopsied blastocysts improve pregnancy outcomes for women with previous IVF-related pregnancy loss? METHODS: This retrospective observational…

INTRODUCTION: The chronic gynecological condition endometriosis affects about 10 percent of reproductive aged women and imposes a heavy physical and psychological burden. The impact of pain and infertility is well documented, but the link b…

Innate lymphoid cells (ILCs) are a newly discovered subset of immune cells that are responsible for regulation of the immune microenvironment. In particular, the ILC categories ILC2s and regulatory ILCs (ILCregs) are associated with immunos…

BACKGROUND: Angiogenesis is a key link in a variety of physiological and pathological processes and plays a crucial role in tissue repair, tumor growth and ischemic diseases. Ginsenosides, as the main active component of ginseng, have a uni…