C. Chapron

Study Objective: To estimate the effect of combined oral contraceptives (COCs) in women with deep infiltrating endometriosis (DIE).Design: Retrospective study (Canadian Task Force classification II-2).Setting: Tertiary care university hospi…

INTRODUCTION: Endometriosis affects approximately 10% of women of reproductive age and is associated with substantial morbidity, including chronic pelvic pain, dysmenorrhea, and infertility. Superficial peritoneal endometriosis (SUP) is the…

STUDY QUESTION: How does adenomyosis affect live birth rates (LBRs) in women undergoing ART compared to a matched control population? SUMMARY ANSWER: Women with adenomyosis, matched with controls for age, blastocyst count, and top-quality b…

STUDY QUESTION: What is the distribution of endometriosis phenotypes according to age in adult women undergoing surgery? SUMMARY ANSWER: The phenotype of endometriosis did not significantly vary after 24 years old. WHAT IS KNOWN ALREADY: …

STUDY QUESTION: Do women with endometriosis who achieve a live birth (LB) after HRT-frozen embryo transfer (HRT-FET) have different progesterone levels on the day of transfer compared to unaffected women? SUMMARY ANSWER: In women achieving …

STUDY QUESTION: Does a reduction in fertility and/or systemic immune cell change occur during the early implantation period in a mouse model of adenomyosis? SUMMARY ANSWER: A reduction in fertility was observed in mice with adenomyosis, co…

Adenomyosis is a benign invasion of endometrial glands and stroma into the uterine myometrium. [1, 2]. It can present with heavy and painful menstrual bleeding or be asymptomatic [2-4]. Over last three decades the diagnosis of adenomyosis h…

The aim of this study is to investigate cancer survival parameters in patients with a combination of adenomyosis and endometrial carcinoma in pathological specimens. This is a retrospective cohort study conducted in a tertiary health center…

STUDY QUESTION: Do severe endometriosis-related painful symptoms impact ART live birth rates? SUMMARY ANSWER: Severe pain symptoms are not associated with reduced ART live birth rates in endometriosis patients. WHAT IS KNOWN ALREADY: ART is…

STUDY QUESTION: Is endometriosis associated with childhood and/or adolescent sexual abuse? SUMMARY ANSWER: Endometriosis is not associated with a history of sexual abuse, unlike the presence of severe pelvic pain. WHAT IS KNOWN ALREADY: S…

Umbilical endometriosis which was first described by Villar in 1886 is a rare clinical entity with a frequency of only 0.5-1%. The overall prevalence rate of endometriosis among women in their reproductive age is put at 5-10%. This is a des…

Introduccin. La asociacin entre endometriosis e infertilidad est claramente definida en la literatura, establecer la relacin fisiopatolgicas entre estas enfermedades dado el impacto que generan en la calidad de vida es un tema de inters en …

Endometriosis is a common problem affecting 5-10% of women of childbearing age. It is a condition with unknown pathology, leaving us with several theories. However, about half of women with endometriosis complain of difficulty conceiving. T…

STUDY QUESTION: What is the impact of adenomyosis on the live birth rate (LBR) in women affected by endometriosis women undergoing ART? SUMMARY ANSWER: For women undergoing ART, the presence of adenomyosis at MRI, especially T2 high-signal …

It is defined by the presence of endometriosis in macroscopically normal-looking tissue. Even though there have been further studies, the meaning of OME is still unclear. Firstly, it could have an important status in the pathogenesis of end…

STUDY QUESTION: Do adenomyosis phenotypes such as external or internal adenomyosis, as diagnosed by MRI, have the same clinical characteristics? SUMMARY ANSWER: External adenomyosis was found more often in young and nulliparous women and wa…

BACKGROUND: Adenomyosis is a benign gynecological disorder associated with subfertility, pelvic pain and abnormal uterine bleeding that have significant consequences for the health and quality of life of women. Histologically, it is defined…

Background. Endometriosis (EMs) is a non-malignant gynecological disease, whose pathogenesis remains to be clarified. Recent studies have found that hypoxia induces epithelial-mesenchymal transition (EMT) as well as epigenetic modification …

The surgical treatment of endometriosis, which used to be performed by laparotomy, is now in most cases performed by coelioscopy. The purpose of surgery is to destroy or remove as much as possible of the endometriotic lesions and to treat t…

Objective To determine whether ileocaecal endometriosis ( ICE ) is a marker for low rectal endometriosis ( LRE ) severity. Design Retrospective cohort study. Setting France. Population and sample Analysis of 375 colorectal resections perfor…

STUDY QUESTION: What are the effects of B lymphocyte inactivation or depletion on the progression of endometriosis? SUMMARY ANSWER: Skewing activated B cells toward regulatory B cells (Bregs) by Bruton's tyrosine kinase (Btk) inhibition usi…