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- mesh:D004715 8
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Add-back hormone replacement therapy (HRT) can alleviate the undesirable hypo-oestrogenic effects of the gonadotrophin-releasing hormone (GnRH) agonists, including loss in bone mineral content. However, this approach presents a dilemma in p…
OBJECTIVE: GnRH analogues are being used increasingly for a number of oestrogen dependent conditions in women. The resultant profound hypo-oestrogenism is a disadvantage, however, but the preservation of pituitary sensitivity to negative fe…
The expression of receptors for the ovarian steroid hormones oestrogen and progesterone was studied immunohistochemically using monoclonal antibodies in samples of endometriosis and endometrium in 22 patients. In nine patients samples of en…
SummaryThe endocrine effects of danazol and goserelin were studied in 10 and 20 women with endometriosis, respectively. Goserelin caused a profound degree of hypogona-dotrophic hypo-oestrogenism comparable with complete ovarian ablation. Da…
SUMMARY In an attempt to determine whether the suppression in oestradiol levels caused by danazol is due to an effect on the hypothalamic‐pituitary axis, we compared the endocrine effects of danazol with those of the LHRH (GnRH) agonist ana…
SummaryForty patients previously diagnosed as having unexplained infertility underwent repeat laparoscopy combined with a simplified cycle of gamete intrafallopian transfer (GIFT). Thirteen patients (33 per cent) had abnormal findings at la…