Wang S

INTRODUCTION: There is increasing evidence that women who have experienced infertility are at greater risk for several chronic conditions. However, the mechanisms underlying these associations are not clear. Pathophysiology may be illuminat…

AIMS/HYPOTHESIS: The aim of the study was to investigate the relationship between infertility history, the risk of type 2 diabetes and HbA1c levels. METHODS: Among the participants in the Nurses' Health Study II (n=116,429), those who repo…

BACKGROUND: The optimal interpregnancy interval (IPI) before reinitiating frozen-thawed embryo transfer (FET) after pregnancy loss remains uncertain, particularly in women undergoing assisted reproductive technology. Current guidelines reco…

Both gut microbiota dysbiosis and altered pelvic immune microenvironment have been linked to endometriosis (EM), but the metabolites connecting the two remain undefined. Combining 16S rDNA sequencing with non-targeted metabolomics in a muri…

BACKGROUND: Endometriosis affects approximately 10% of women of reproductive age worldwide. Although elemental components of refluxed menstrual blood have been implicated in disease progression, comprehensive ionomic profiling of the endome…

OBJECTIVE: To evaluate the long-term therapeutic efficacy of uterine artery embolization (UAE) for adenomyosis and to identify independent prognostic factors associated with postoperative recurrence. METHODS: A total of 200 adenomyosis pati…

Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder with a complex and yet unresolved etiology. Although ovulation induction therapy can improve ovulatory function, the natural pregnancy rate and pregnancy outco…

BACKGROUND: Ovarian cancer is a major female reproductive health issue with heterogeneous biological features on its subtypes, which may require different therapeutic strategies. Glucagon-like peptide-1 receptor (GLP-1R) agonists were repor…

BACKGROUND: Oocyte aneuploidy is a major cause of pregnancy failure in women of advanced maternal age (AMA), and current assisted reproductive technologies offer limited effective strategies to prevent age-related decline in oocyte quality.…

Pelvic organ prolapse (POP) is a prevalent condition that significantly impairs women's quality of life and is closely linked to dysregulated estrogen signaling. This review examines the mechanisms through which estrogen, acting via nuclear…

BACKGROUND: Endometriosis is a complex gynaecological disorder that affects 10%-15% of reproductive-age women and is characterized by chronic inflammation, pelvic pain, and infertility. Although mitochondrial dysfunction is implicated in en…

PURPOSE: Temporary ileostomy is commonly performed to protect rectal anastomosis after rectal surgery, yet the optimal timing of reversal remains unsettled. This study compared postoperative outcomes among early, intermediate, and late ileo…

PURPOSE: The goal of optimizing electrogram acquisition in electrophysiology imaging is to minimize the number of electrodes used, determine their optimal placement, and ensure accurate imaging. METHODS: We quantitatively evaluated the imp…

BACKGROUND: Accurate prediction of the biological behavior of cervical squamous cell carcinoma (CSCC) is essential for optimizing therapeutic strategies and enhancing patient outcomes. This study aims to develop and validate a radiomics nom…

BACKGROUND: Infertility affects many couples worldwide, and the accurate assessment of endometrial receptivity (ER) is critical. However, conventional ultrasound has limited predictive value. Multiparameter quantitative ultrasound is a prom…

BACKGROUND: Reactive nodular fibrous pseudotumor is a rare benign fibroinflammatory lesion of the gastrointestinal tract and mesentery that can closely mimic malignant disease on clinical examination and imaging. Most reported cases are ass…

Endometriosis is a common gynecological disorder characterized by the ectopic growth of endometrium-like tissue outside the uterine cavity and is associated with pelvic pain, infertility, and reduced quality of life. Although several theori…

Xinyue Cui,1 Jiaxuan Liu,2 Shengwu Wang,2 Huali Xu,2 Yali Fang,2 Guiping Wan,1 Rui Rui,3 Hong Zhu21Department of Obstetrics and Gynecology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Ch…

BACKGROUND: Endometriosis is a leading cause of chronic pelvic pain (CPP), but the public transcriptomic datasets analysed here contain no pain phenotype, links to CPP are therefore hypothesis-generating. METHODS: We re-analysed GSE153739 …

ObjectivesThis study investigated the protective effects and mechanisms of rhaponticin (Rha) against acinar cell injury in acute pancreatitis (AP).MethodsPancreatic acinar cell injury was induced using multiple in vitro and in vivo AP model…

BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with an increased risk of type 2 diabetes mellitus (T2DM), and the risk of PCOS increases in patients with T2DM of reproductive age. The bidirectional link between PCOS and T2DM has…

Precancers, defined as normal-appearing or morphologically altered tissues with a risk of oncogenesis, exhibit various detectable manifestations across anatomical sites, including epithelial dysplasia, metaplasia, hyperplasia, and stromal f…

Endometriosis (EM) is driven by immune dysregulation and macrophage dysfunction, yet the underlying mechanisms remain unclear. Here, metabolomic profiling revealed excessive itaconate accumulation in EM lesions, primarily due to elevated ci…