Shay M. Freger

ORCID: 0000-0001-5534-3965 · 26 papers in corpus · active 2020-2026

Study types

  • article 12
  • other 6
  • review 4
  • preprint 3
  • book-chapter 1

Condition tags

  • endometriosis 25
  • mesh:D004715 10
  • infertility 5
  • chronic_pelvic_pain 4
  • mesh:D017699 3
  • dyspareunia 2
  • endometrioma 2
  • dysmenorrhea 2
other 2026
Acta obstetricia et gynecologica Scandinavica ·doi:10.1111/aogs.70167

INTRODUCTION: Endometriosis is a heterogeneous pain condition with variable symptom expression. Abuse history has been associated with amplified pain, gastrointestinal symptoms, and central sensitization in varying populations; however, whe…

other 2026
European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2026.114947

OBJECTIVE: To (1) determine how application of the updated international definition of deep endometriosis (DE) alters apparent disease prevalence across pelvic sites, and (2) characterize the distribution of endometriosis phenotypes, includ…

article 2026

In this study, we evaluate a locally-deployed large-language model (LLM) to convert unstructured endometriosis transvaginal ultrasound (eTVUS) scan reports into structured data for imaging informatics workflows. Across 49 eTVUS reports, we …

other 2026
BJOG: An International Journal of Obstetrics & Gynaecology ·doi:10.1111/1471-0528.70188

OBJECTIVE: To explore diagnostic preferences among individuals with confirmed or suspected endometriosis to inform the development of patient-centred diagnostic strategies. DESIGN: Qualitative study using semi-structured focus group discus…

preprint 2026
·doi:10.2139/ssrn.6068273
article 2026
·doi:10.1145/3772363.3798872

In this study, we evaluate locally deployed large language models (LLMs) for converting unstructured endometriosis transvaginal ultrasound (eTVUS) reports into structured data. Across 49 de-identified reports, we compared three on-premise L…

preprint 2026
·doi:10.48550/arxiv.2601.09053

In this study, we evaluate a locally-deployed large-language model (LLM) to convert unstructured endometriosis transvaginal ultrasound (eTVUS) scan reports into structured data for imaging informatics workflows. Across 49 eTVUS reports, we …

review 2025
Gynecologic and obstetric investigation ·doi:10.1159/000543075

BACKGROUND: Endometriosis is a chronic disease characterized by endometrial-like tissue outside the uterus. Superficial endometriosis (SE) is the most prevalent form, yet it remains underdiagnosed due to subtle clinical and imaging presenta…

other 2025
O&G open ·doi:10.1097/og9.0000000000000061

OBJECTIVE: To evaluate the diagnostic accuracy of transvaginal ultrasonography (TVUS) in detecting deep endometriosis, ovarian endometriosis, and superficial endometriosis using the IDEA (International Deep Endometriosis Analysis) consensus…

article 2025
Australasian journal of ultrasound in medicine ·doi:10.1002/ajum.70021

Objective: To assess the impact of complex disease states, including pouch of Douglas (POD) obliteration and deep endometriosis (DE) of the bowel, on the diagnostic accuracy of transvaginal ultrasound (TVUS) for detecting endometriosis of t…

article 2025
·doi:10.22541/au.175952356.67166207/v1

ABSTRACT Objective: To explore diagnostic preferences among individuals with confirmed or suspected endometriosis to inform the development of patient-centered diagnostic strategies. Design: Qualitative study using semi-structured focus gro…

article 2025
Acta obstetricia et gynecologica Scandinavica ·doi:10.1111/aogs.70096

INTRODUCTION: Understanding what patients prioritize when seeking care for endometriosis and chronic pelvic pain (CPP) is crucial for delivering personalized, responsive care. However, patient-defined goals remain poorly characterized acros…

preprint 2025
·doi:10.1101/2025.09.19.25336201

Abstract BACKGROUND Patients with endometriosis experience chronic, inflammatory symptoms including severe pelvic pain and infertility, caused by endometrial-like tissue growth outside the uterus. Endometriosis remains poorly understood, la…

article 2025
Reproduction & fertility ·doi:10.1530/raf-25-0164

Lay summary: Endometriosis is a chronic condition where tissue resembling the uterine lining grows elsewhere in the pelvis, often causing pain, infertility, and inflammation. For decades, textbooks and research papers have described the rec…

article 2025
·doi:10.1016/j.jeud.2025.100131

• High prevalence of severe dysmenorrhea in patients with PCOM. • Heavy menstrual flow strongly predicts severe dysmenorrhea. • Gravidity appears protective against severe menstrual pain. • PCOM identified in nearly 20% of gynecologic ultra…

review 2024
Therapeutic advances in reproductive health ·doi:10.1177/26334941241277759

Endometriosis is a prevalent gynecological disease, leading to chronic pain and inflammation, affecting 1 in 10 individuals presumed female at birth. The diagnostic journey is often arduous, marked by neglect of the right diagnosis and prol…

article 2024
·doi:10.1002/uog.29012

Transvaginal ultrasound (TVS) is crucial for diagnosing endometriosis, guided by the International Deep Endometriosis Analysis (IDEA) guidelines. While TVS excels in diagnosing ovarian (OE) and deep endometriosis (DE), superficial endometri…

other 2024
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.12.008

Endometriosis affects 1 in 9 women and those assigned female at birth. However, it takes 6.4 years to diagnose using the conventional standard of laparoscopy. Noninvasive imaging enables a timelier diagnosis, reducing diagnostic delay as we…

other 2024
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology ·doi:10.1002/uog.27492

OBJECTIVE: To determine the diagnostic test accuracy of transvaginal ultrasound (TVS) using a standardized technique for the diagnosis of deep endometriosis (DE) of the uterosacral ligaments (USLs) and adjacent torus uterinus (TU). METHODS…

review 2023
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.12.017
article 2023
·doi:10.1002/uog.26376

The uterosacral ligaments (USLs) and torus uterinus (TU) are common sites for deep endometriosis (DE) but are challenging to diagnose through transvaginal ultrasound (TVS). Anatomical distortion caused by severe endometriosis, including pou…

article 2023
·doi:10.1002/uog.26380

An up-to-date description of ovarian and deep endometriosis distribution is necessary as the diagnostic algorithm now includes ultrasound as a highly specific diagnostic test. The primary objective was to describe ovarian/deep endometriosis…

article 2023
·doi:10.1002/uog.26519

The primary objective of this study is to establish whether ultrasound (US) diagnosis of endometriosis affects patient decision-making on treatment options. Secondary objectives include determining: 1) patient comfort of endometriosis US; 2…

article 2023
·doi:10.5256/f1000research.154963.r208441
review 2021
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2021.05.022