Geraldine O Canny

No ORCID on file · 7 papers in corpus · active 2011-2017

Study types

  • other 4
  • article 3

Condition tags

  • endometriosis 7
  • mesh:D004715 4
  • infertility 2
  • chronic_pelvic_pain 1
other 2017
Disrupting Y-Box-Binding Protein 1 Function Using OSU-03012 Prevents Endometriosis Progression in In Vitro and In Vivo Models
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719116649695

The objective of the present study was to test the ability of OSU-03012 (2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide), a novel and potent celecoxib-derivative, to impair endometriosis progression in in …

article 2016
Proteome-Wide Effect of 17-β-Estradiol and Lipoxin A4 in an Endometriotic Epithelial Cell Line
Frontiers in endocrinology ·doi:10.3389/fendo.2015.00192

Endometriosis affects approximately 10% of women of reproductive age. This chronic, gynecological inflammatory disease results in a decreased quality of life for patients, with the main symptoms including chronic pelvic pain and infertility…

other 2014
Lipoxin A₄ prevents the progression of de novo and established endometriosis in a mouse model by attenuating prostaglandin E₂ production and estrogen signaling
PloS one ·doi:10.1371/journal.pone.0089742

Endometriosis, a leading cause of pelvic pain and infertility, is characterized by ectopic growth of endometrial-like tissue and affects approximately 176 million women worldwide. The pathophysiology involves inflammatory and angiogenic med…

other 2013
Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4)
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.01.146

OBJECTIVE: To compare the expression of the prostaglandin (PG) E(2) transporter multidrug resistance-associated protein 4 (MRP4) in eutopic and ectopic endometrial tissue from endometriosis patients with that of control subjects and to exam…

article 2013
L1 Cell Adhesion Molecule as a Potential Therapeutic Target in Murine Models of Endometriosis Using a Monoclonal Antibody Approach
PloS one ·doi:10.1371/journal.pone.0082512

BACKGROUND/AIMS: The neural cell adhesion molecule L1CAM is a transmembrane glycoprotein abnormally expressed in tumors and previously associated with cell proliferation, adhesion and invasion, as well as neurite outgrowth in endometriosis.…

article 2012
The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.06.056
other 2011
Tumor necrosis factor-α activates estrogen signaling pathways in endometrial epithelial cells via estrogen receptor α
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2011.06.043

The pro-inflammatory cytokine TNF-α and the female hormone estrogen have been implicated in the pathophysiology of two common gynecological diseases, endometriosis and endometrial adenocarcinoma. Here we describe a novel capacity of TNF-α t…