Brooke E Howitt

Mesonephric-like adenocarcinoma (MLA) is a rare and aggressive gynecologic malignancy that has only been recognized in the last decade. It arises in the endometrium, ovaries, and other extrauterine sites (often in association with endometri…

Mesonephric adenocarcinomas (MAs) and mesonephric-like adenocarcinomas (MLAs) are rare, aggressive neoplasms that arise in the gynecologic tract and show overlapping morphologic, immunohistochemical, and molecular features. While MAs occur …

Supplemental Figure 1: Kaplan Meier Survival Curves by TCGA Molecular Subtype

Supplemental Figure 1: Kaplan Meier Survival Curves by TCGA Molecular Subtype

Supplemental Figure 2: Schoenfeld’s test of proportional hazards for multivariate Cox analysis including CINSARC and EcoTyper Classifiers.

Supplemental Figure 2: Schoenfeld’s test of proportional hazards for multivariate Cox analysis including CINSARC and EcoTyper Classifiers.

Supplemental Figure 3: EERI Values in TCGA Subtypes. A) The Stanford-EEC cohort and subgroups. B) The TCGA-UCEC cohort and subgroups. P-values generated by Whitney-Mann U test. Error bars represent 95% confidence intervals.

Supplemental Figure 3: EERI Values in TCGA Subtypes. A) The Stanford-EEC cohort and subgroups. B) The TCGA-UCEC cohort and subgroups. P-values generated by Whitney-Mann U test. Error bars represent 95% confidence intervals.

Supplemental Figure 4: Recurrence Free Survival stratified by EERI score for Stages I-IV disease in the TCGA-UCEC Cohort. Patients with EEC by stage at diagnosis. Patients were included with more than 1 year of follow-up and known endometri…

Supplemental Figure 4: Recurrence Free Survival stratified by EERI score for Stages I-IV disease in the TCGA-UCEC Cohort. Patients with EEC by stage at diagnosis. Patients were included with more than 1 year of follow-up and known endometri…

Supplemental Table 1: Genes used in EERI listed by prognostic impact.

Supplemental Table 1: Genes used in EERI listed by prognostic impact.

Supplemental Table 2: Clinical and Pathologic Variables of Cases and EERI False Negatives in both the Stanford-EEC cases and TCGA-UCEC recurrent patients

Supplemental Table 2: Clinical and Pathologic Variables of Cases and EERI False Negatives in both the Stanford-EEC cases and TCGA-UCEC recurrent patients

Supplemental Table 3: Clinical and Pathologic Variables of Controls and EERI False Positives in both the Stanford-EEC controls and TCGA-UCEC non-recurrent patients

Supplemental Table 3: Clinical and Pathologic Variables of Controls and EERI False Positives in both the Stanford-EEC controls and TCGA-UCEC non-recurrent patients

Clear cell carcinomas are rare and relatively chemo-insensitive ovarian cancers with a characteristic molecular pathogenesis. Alterations in ARID1A, a component of the multiprotein chromatin remodeling complex SWI/SNF, are likely early even…

Endometriosis is generally histopathologically defined as the presence of at least 2 of the following: endometrial stroma, Müllerian epithelium, and/or hemosiderin-laden macrophages (HLM). Despite clinically evident endometriotic lesions, b…

Mesonephric adenocarcinoma most commonly arises in the cervix and is presumed to be derived from normal or hyperplastic mesonephric remnants. It is characterized by recurrent KRAS mutations and lack of PIK3CA/PTEN alterations. Adenocarcinom…

5514 Background: Studies of immune checkpoint inhibitors (e.g., anti-PD-1/PD-L1 antibodies) in ovarian cancer have demonstrated isolated responses in tumors with clear cell histology. In order to assess the immunogenicity of clear cell ovar…

Primary sporadic gene-inactivating events within the progesterone response cascade might explain the presence of individual dyssynchronous (outlier) glands commonly observed in a secretory background. We queried morphologically dyssynchrono…

OBJECTIVES: To identify the sonographic features of decidualized endometriomas in patients treated at a single institution and to determine whether sonographic findings can distinguish these lesions from malignant ovarian tumors during preg…