A.A. Stepanian

Benign uterine diseases remain among the leading causes of surgical interventions in women of reproductive age. A forty-year cumulative clinical experience (1986—2026) demonstrates that the effectiveness of reconstructive and uterus-preserv…

This systematic review aimed to summarize all available data and evaluate the roles of E-cadherin, N-cadherin, associated molecules, and signaling pathways in the pathogenesis of endometriosis. The search was conducted on PubMed, Cochrane L…

Endometriosis is a gynecological disorder characterized by the presence of endometrium-like tissue outside the uterine cavity and, in many cases, by a chronic and recurrent clinical course. This review synthesizes current evidence on the ge…

The article focuses on the of methods for objectifying pain syndrome in patients with endometriosis. Endometriosis-related pain, including dysmenorrhea, dyspareunia, and chronic pelvic pain, is a clinically significant symptom of the diseas…

Background/Objectives: The diagnosis and treatment of endometriosis should be based on the best available evidence. Emphasising the risk of bias, the pyramid of evidence has the double-blind, randomised controlled trial and its meta-analyse…

Objective. Optimization of diagnostic methods for studying the myometrium in adenomyosis using magnetic resonance imaging (MRI) and subsequent construction of a three-dimensional model of the uterus using computer-assisted technologies to o…

• Endometriosis shows significant variation in its presentation and pathophysiology and is closely linked to fibrosis. • There is a critical need to provide insights in pathophysiology of endometriosis and to find new biomarkers and targets…

The mammary gland is a paired organ of the reproductive system, belonging to the type of apocrine glands of the skin. The main function of the mammary gland is the synthesis and secretion of milk. The structure and function of the mammary g…

Endometriosis is a gynaecological disease characterised by the presence of tissue with morphological and functional properties similar to endometrium outside the uterine cavity. This pathology affects about 10% of women of reproductive age …

Endometriosis is a gynecological disease characterized by the presence of tissue that is morphologically and functionally similar to the endometrium, but located outside the uterine cavity, with a chronic and recurrent course. According to …

The purpose of this systematic review was to identify potential metabolomic biomarkers of endometriosis in plasma, serum, peritoneal fluid, follicular fluid, urine, endometrial tissue samples of patients with endometriosis. Search was condu…

Endometriosis is a gynecological disease that affects up to 10% of women of reproductive age and is characterized by pronounced heterogeneity of clinical manifestations and pathogenetic mechanisms. Despite significant advances in diagnostic…

The article focuses on the role of oxidative stress, ferroptosis, and antioxidant therapy in the pathogenesis and treatment of endometriosis — a gynecological condition affecting up to 10% of women of reproductive age. Oxidative stress and …

Evidence-based data for endometriosis management are limited. Experiments are excluded without adequate animal models. Data are limited to symptomatic women and occasional observations. Hormonal medical therapy cannot be blinded if recognis…

Evidence-based data for endometriosis management are limited. Experiments are excluded without adequate animal models. Data are limited to symptomatic women and occasional observations. Hormonal medical therapy cannot be blinded if recognis…