Wan R

No ORCID on file · 4 papers in corpus
other 2026
IL18 Works Like a Two-Side Coin in Acute Pancreatitis
International journal of general medicine ·doi:10.2147/ijgm.s606433

PURPOSE: Acute pancreatitis is a common disease with limited supportive treatments. Finding effective biomarkers is of great significance for early diagnosis and therapy, as well as to achieve better prognosis. MATERIALS AND METHODS: The c…

observational 2021
Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians
Genome medicine ·doi:10.1186/s13073-021-00831-z

BACKGROUND: The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear. METHODS: We used data from Biobank Japan (n = 70,657-128,305) and …

lab-animal 2020
Myeloid-specific dopamine D2 receptor signalling controls inflammation in acute pancreatitis via inhibiting M1 macrophage
British journal of pharmacology ·doi:10.1111/bph.15026

BACKGROUND AND PURPOSE: Macrophage infiltration and activation is a critical step during acute pancreatitis (AP). We have shown that pancreas-specific D2 receptor signalling protects against AP severity. As it is unclear to what extent myel…

lab-animal 2017
Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway
British journal of pharmacology ·doi:10.1111/bph.14057

BACKGROUND AND PURPOSE: Dopamine has multiple anti-inflammatory effects, but its role and molecular mechanism in acute pancreatitis (AP) are unclear. We investigated the role of dopamine signalling in the inflammatory response in AP. EXPER…