German Cano-Sancho

observational 2024

A comprehensive multiplatform metabolomic analysis reveals alterations of 2-hydroxybutyric acid among women with deep endometriosis related to the pesticide trans-nonachlor

The Science of the total environment ·doi:10.1016/j.scitotenv.2024.170678

BACKGROUND: Exposure to persistent organic pollutants (POPs) has been related to the risk of endometriosis however the mechanisms remain unclear. The objective of the present study was to characterize the metabolic profiles underpinning the…

review 2023

Application of AOPs to assist regulatory assessment of chemical risks - Case studies, needs and recommendations

Environmental research ·doi:10.1016/j.envres.2022.114650

While human regulatory risk assessment (RA) still largely relies on animal studies, new approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative models are increasingly used to evaluate chemical hazards. Moreo…

review 2022

Partitioning of Persistent Organic Pollutants between Adipose Tissue and Serum in Human Studies

Toxics ·doi:10.3390/toxics11010041

Blood is the most widely used matrix for biomonitoring of persistent organic pollutants (POPs). It is assumed that POPs are homogenously distributed within body lipids at steady state; however, the variability underlying the partitioning of…

meta-analysis 2021

Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence

Environmental health perspectives ·doi:10.1289/ehp8421

BACKGROUND: Growing epidemiological evidence suggests that organochlorine chemicals (OCCs), including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), may play a role in the pathogenesis of endometriosis. OBJECTIVES: We aimed to systematically …

observational 2021

Associations between persistent organic pollutants and endometriosis: A multiblock approach integrating metabolic and cytokine profiling

Environment international ·doi:10.1016/j.envint.2021.106926

Humans are exposed daily to complex mixtures of chemical pollutants through their environment and diet, some of which have the potential to disrupt the bodies' natural endocrine functions and contribute to reproductive diseases like endomet…

observational 2020

Associations between persistent organic pollutants and endometriosis: A multipollutant assessment using machine learning algorithms

Environmental pollution (Barking, Essex : 1987) ·doi:10.1016/j.envpol.2020.114066

Endometriosis is a gynaecological disease characterised by the presence of endometriotic tissue outside of the uterus impacting a significant fraction of women of childbearing age. Evidence from epidemiological studies suggests a relationsh…

other 2019

Associations between exposure to organochlorine chemicals and endometriosis in experimental studies: A systematic review protocol

Environment international ·doi:10.1016/j.envint.2018.12.063

BACKGROUND: Endometriosis is a hormone-dependent gynaecological disease characterised by the presence and growth of endometrial tissues outside of the uterus. There is growing experimental evidence that suggests environmental endocrine disr…

meta-analysis 2019

Human epidemiological evidence about the associations between exposure to organochlorine chemicals and endometriosis: Systematic review and meta-analysis

Environment international ·doi:10.1016/j.envint.2018.11.065

BACKGROUND: Endometriosis is a gynaecological disease characterized by the presence of ectopic endometrial tissue that affects women during their reproductive years, having a strong impact on their lives, fertility and healthcare costs. The…

other 2018

The challenging use and interpretation of circulating biomarkers of exposure to persistent organic pollutants in environmental health: Comparison of lipid adjustment approaches in a case study related to endometriosis

Chemosphere ·doi:10.1016/j.chemosphere.2018.02.120

The gold-standard matrix for measuring the internal levels of persistent organic pollutants (POPs) is the adipose tissue, however in epidemiological studies the use of serum is preferred due to the low cost and higher accessibility. The int…

observational 2017

Associations between internal exposure levels of persistent organic pollutants in adipose tissue and deep infiltrating endometriosis with or without concurrent ovarian endometrioma

Environment international ·doi:10.1016/j.envint.2017.08.019

Endometriosis is a gynaecological disease characterized by the presence of ectopic endometrial tissue. Histologically, it appears as different sub-types, being peritoneal endometriosis, ovarian endometrioma (OvE) and deep infiltrating endom…