Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence

Komodo Matta, Meriem Koual, Stéphane Ploteau, Xavier Coumoul, Karine Audouze, Bruno Le Bizec, Jean‐Philippe Antignac, Jean-Philippe Antignac, Germán Cano-Sancho, German Cano-Sancho
Environmental health perspectives · 2021 · vol. 129(7) , pp. 76003 · doi:10.1289/ehp8421 · PMID:34310196 · W3183326671
review OA: diamond CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This systematic review of experimental studies found associations between organochlorine chemical exposure and endometriosis end points, supported by evidence on aryl hydrocarbon receptor, matrix metalloproteinases, and estrogen interactions.

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Abstract

BACKGROUND: -dioxin (TCDD), may play a role in the pathogenesis of endometriosis. OBJECTIVES: ) on the associations between exposure to OCCs and endometriosis-related end points. METHODS: evidence further supported the roles of the aryl hydrocarbon receptor and matrix metalloproteinases in mediating steroidogenic disruption and inflammatory responses. Estrogen interactions were found across studies and end points. CONCLUSION: evidence. Nonetheless, there is need for further research to fill in our gaps in understanding of the relationship between OCCs and their mixtures and endometriosis, beyond the prototypical TCDD. https://doi.org/10.1289/EHP8421.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Dioxins Dioxins Endometriosis Endometriosis Endometriosis Hydrocarbons, Chlorinated Polychlorinated Dibenzodioxins Polychlorinated Dibenzodioxins Animals Cell Culture Techniques Cell Proliferation Environmental Exposure Environmental Exposure Female Humans Hydrocarbons, Chlorinated

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (13)

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