Shiru Xu — Endo Lab

lab-animal 2026

C/EBPδ regulates SPHK1-dependent excessive autophagy in decidualization defects of chronic endometritis

Reproduction (Cambridge, England) ·doi:10.1093/reprod/xaag111

In brief: Chronic endometritis (CE) impairs endometrial receptivity via unknown mechanisms. This study reveals that suppression of the C/EBPδ-sphingosine kinase 1 (SphK1)-sphingosine-1-phosphate (S1P) axis in CE leads to decidualization def…

observational 2026

Genetic landscape of human oocyte/embryo defects

Cell genomics ·doi:10.1016/j.xgen.2025.101012

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

observational 2022

Endometriosis is associated with a lowered cumulative live birth rate: A retrospective matched cohort study including 3071 in vitro fertilization cycles

Journal of Reproductive Immunology ·doi:10.1016/j.jri.2022.103631

Endometriosis, defined as the presence of endometrial tissues outside the uterus, affects approximately 10% of women of reproductive age. Assisted reproductive technology (ART) is considered the most effective technique to treat infertility…

observational 2022

O-191 Endometriosis is associated with a lowered cumulative live birth rate by alters the macrophage polarization and the cytokine concentrations in follicular fluid

·doi:10.1093/humrep/deac106.101

Abstract Study question The impact of endometriosis on the outcomes of ART is still ambiguous and the mechanism by which endometriosis impacts fertility has not been fully elucidated Summary answer Endometriosis was associated with low CLBR…

observational 2018

Study on the incidence and influences on heterotopic pregnancy from embryo transfer of fresh cycles and frozen-thawed cycles

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-017-1109-x

PURPOSE: The purpose of this study was to determine the heterotopic pregnancy rate using fresh versus frozen-thawed embryo transfers and factors associated with heterotopic pregnancy (HP). Management and clinical outcomes after heterotopic …