[Effects of Coleus forskohlii on fat storage in ovariectomized rats]

Li-Kun Han, Chie Morimoto, Rong-Hai YU, Hiromichi Okuda
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan · 2005 · vol. 125(5) , pp. 449–453 · doi:10.1248/yakushi.125.449 · PMID:15863977 · W2022195530
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Coleus forskohlii extract reduced body weight, food intake, and fat accumulation in ovariectomized rats, indicating potential utility for obesity treatment.

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This study investigated the antiobesity effects of Coleus forskohlii extract in ovariectomized female Wistar rats. The researchers divided eight-week-old rats into four groups, comparing those fed a control diet against those receiving a diet supplemented with 50 g/kg of the extract. Results indicated that administration of the extract significantly reduced body weight, food intake, and fat accumulation in the ovariectomized subjects. While the authors suggest potential utility for obesity treatment, the paper focuses solely on metabolic outcomes in rodent models without addressing reproductive pathology. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The antiobesity effects of Coleus forskohlii were investigated in ovariectomized (ovx) rats. Eight-week-old female Wistar rats were assigned to four groups: a sham-operated group fed the control diet (MF, sham-m) ; an ovx-m group fed the control diet; a sham-operated group fed the control diet containing 50 g/kg of Coleus forskohlii extract (sham-c) ; and an ovx-c group fed the control diet containing 50 g/kg of Coleus forskohlii extract. The body weight, adipose tissues, and cell diameter were investigated in ovx rats after Coleus forskohlii extract treatment. Administration of Coleus forskohlii extracts reduced body weight, food intake, and fat accumulation in ovx rats. Our results suggest that Coleus forskohlii may be useful in the treatment of obesity.
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一般論文 卵巣摘出ラットの脂肪蓄積に及ぼすコレウスフォルスコリの影響 2005 年 125 巻 5 号 p. 449-453 詳細 抄録 The antiobesity effects of Coleus forskohlii were investigated in ovariectomized (ovx) rats. Eight-week-old female Wistar rats were assigned to four groups: a sham-operated group fed the control diet (MF, sham-m) ; an ovx-m group fed the control diet; a sham-operated group fed the control diet containing 50 g/kg of Coleus forskohlii extract (sham-c) ; and an ovx-c group fed the control diet containing 50 g/kg of Coleus forskohlii extract. The body weight, adipose tissues, and cell diameter were investigated in ovx rats after Coleus forskohlii extract treatment. Administration of Coleus forskohlii extracts reduced body weight, food intake, and fat accumulation in ovx rats. Our results suggest that Coleus forskohlii may be useful in the treatment of obesity. © 2005 by the PHARMACEUTICAL SOCIETY OF JAPAN

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MeSH descriptors

Coleus Lipid Metabolism Obesity Obesity Ovariectomy Plant Extracts Adipocytes Adipocytes Adipocytes Adipose Tissue Adipose Tissue Animals Body Weight Body Weight Colforsin Colforsin Colforsin Energy Metabolism Energy Metabolism Female

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