An investigational ovarian stimulation protocol increased significantly the psychological burden in women with premature ovarian failure

Johnny T Awwad; Johnny Awwad; Ghina S Ghazeeri; Ghina Ghazeeri; Antoine Hannoun; Keith Isaacson; Michel Abou-Abdallah; Chantal G Farra; Chantal Farra

doi:10.1111/aogs.12004

An investigational ovarian stimulation protocol increased significantly the psychological burden in women with premature ovarian failure

Johnny T Awwad, Johnny Awwad, Ghina S Ghazeeri, Ghina Ghazeeri, Antoine Hannoun, Keith Isaacson, Michel Abou-Abdallah, Chantal G Farra, Chantal Farra

Acta obstetricia et gynecologica Scandinavica · 2012 · vol. 91(11) , pp. 1273–1278 · doi:10.1111/aogs.12004 · PMID:22994379 · W1586526765

Non-randomised trial OA: closed CC0

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This study found that an investigational ovarian stimulation protocol in women with premature ovarian failure significantly increased anxiety and depression scores compared to baseline.

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Abstract

OBJECTIVE: To assess the psychological impact (Hospital Anxiety and Depression Scale) of an investigational ovarian stimulation protocol in women with premature ovarian failure (POF). DESIGN: Prospective longitudinal study. POPULATION: Ten women with POF. METHODS: Women with idiopathic POF were placed on three consecutive treatment cycles consisting of gonadotropin ovarian stimulation after estrogen priming, gonadotropin-releasing hormone agonist pituitary desensitization, and corticosteroid immune suppression. RESULTS: Median anxiety and depression scores increased significantly from baseline following three consecutive treatment cycles from 4.0 (range 2.0-8.0) to 11.0 (range 10.0-14.0) (p-value 0.041) and from 1.5 (range 0-6.0) to 9.0 (range 7.0-10.0) (p-value 0.039), respectively. There were nine "probable" anxiety (90%) and three "probable" depression (30%) cases on the final treatment cycle compared with none (0%) on baseline (p-value 0.004 and 0.250, respectively). CONCLUSIONS: The use of investigational ovarian stimulation protocols in women with idiopathic POF was associated with excessive psychological strain. Women with POF should be cautioned against the potentially harmful aspect of similar treatments of unproven benefit.

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MeSH descriptors

Infertility, Female Ovulation Induction Primary Ovarian Insufficiency Adolescent Adult Anxiety Anxiety Buserelin Buserelin Chorionic Gonadotropin Chorionic Gonadotropin Depression Depression Estrogens Estrogens Estrogens, Conjugated (USP) Estrogens, Conjugated (USP) Female Glucocorticoids Glucocorticoids

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Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

High-dose, short-term glucocorticoids for the treatment of infertility resulting from premature ovarian failure 1993

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[1] High-dose, short-term glucocorticoids for the treatment of infertility resulting from premature ovarian failure 1993