Death Receptor 6 is Epigenetically Silenced by Histone Deacetylation in Endometriosis and Promotes the Pathogenesis of Endometriosis

Kentaro Kai
2014 · W7145564215
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This research found that Death Receptor 6 is epigenetically silenced by histone deacetylation in endometriosis, contributing to the disease's pathogenesis.

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The study investigates the role of Death Receptor 6 (DR6) in endometriosis, revealing that DR6 expression is significantly reduced in ectopic endometrial tissues compared to eutopic counterparts. Researchers identified that this downregulation results from epigenetic silencing via histone deacetylation, a mechanism confirmed by the restoration of DR6 levels following treatment with histone deacetylase inhibitors. Functional assays demonstrated that reintroducing DR6 into endometriotic cells inhibited cell proliferation and migration, indicating its tumor-suppressive function in this context. This paper is centrally about endometriosis — specifically examining how epigenetic silencing of DR6 contributes to disease pathogenesis by promoting cell survival and spread.

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WEKO3 アイテム Death Receptor 6 is Epigenetically Silenced by Histone Deacetylation in Endometriosis and Promotes the Pathogenesis of Endometriosis http://hdl.handle.net/10559/15603 http://hdl.handle.net/10559/15603ba4d0e7c-f86a-461c-a8a5-4ea02ad0f575 | 名前 / ファイル | ライセンス | アクション | |---|---|---| | ko511.pdf | | | アイテムタイプ | デフォルトアイテムタイプ（フル）(1) | ||||||||||| |---|---|---|---|---|---|---|---|---|---|---|---|---| | 公開日 | 2016-06-09 | ||||||||||| | タイトル | |||||||||||| | タイトル | Death Receptor 6 is Epigenetically Silenced by Histone Deacetylation in Endometriosis and Promotes the Pathogenesis of Endometriosis | ||||||||||| | 言語 | en | ||||||||||| | 作成者 | 甲斐, 健太郎 × 甲斐, 健太郎 | ||||||||||| | アクセス権 | |||||||||||| | アクセス権 | open access | ||||||||||| | アクセス権URI | http://purl.org/coar/access_right/c_abf2 | ||||||||||| | 権利情報 | |||||||||||| | 権利情報 | The final publication is available at https://doi.org/10.1111/aji.12155. Kai K、 Nasu K、 Kawano Y、 Aoyagi Y、 Tsukamoto Y、 Hijiya N、 Abe W、 Okamoto M、 Moriyama M、 Narahara H. Death receptor 6 is epigenetically silenced by histone deacetylation in endometriosis and promotes the pathogenesis of endometriosis. Am J Reprod Immunol. 2013 Dec;70(6):485-96. | ||||||||||| | 言語 | en | ||||||||||| | 出版者 | |||||||||||| | 出版者 | 大分大学 | ||||||||||| | 言語 | ja | ||||||||||| | 日付 | |||||||||||| | 日付 | 2014-01-01 | ||||||||||| | 日付タイプ | Issued | ||||||||||| | 言語 | |||||||||||| | 言語 | eng | ||||||||||| | 資源タイプ | |||||||||||| | 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | ||||||||||| | 資源タイプ | doctoral thesis | ||||||||||| | 識別子 | |||||||||||| | 識別子 | http://hdl.handle.net/10559/15603 | ||||||||||| | 識別子タイプ | HDL | ||||||||||| | 関連情報 | |||||||||||| | 関連タイプ | isVersionOf | ||||||||||| | 識別子タイプ | DOI | ||||||||||| | 関連識別子 | https://doi.org/10.1111/aji.12155 | ||||||||||| | 学位授与番号 | |||||||||||| | 学位授与番号 | 甲第511号 | ||||||||||| | 学位名 | |||||||||||| | 学位名 | 博士(医学) | ||||||||||| | 言語 | ja | ||||||||||| | 学位授与年月日 | |||||||||||| | 学位授与年月日 | 2014-03-25 | ||||||||||| | 学位授与機関 | |||||||||||| | 学位授与機関名 | 大分大学 | ||||||||||| | 言語 | ja |

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endometriosis

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