Evaluation of cryogenine on rat paw thermal oedema and rat isolated uterus

Marvin H. Malone, M H Malone, Ralph W. Trottier, R W Trottier
British journal of pharmacology · 1973 · vol. 48(2) , pp. 255–262 · doi:10.1111/j.1476-5381.1973.tb06911.x · PMID:4733728 · PMC1776235 · W1966928216
Lab / animal OA: bronze CC0
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This study evaluated cryogenine, finding it significantly inhibited thermal edema in rats when administered daily but not as a single dose, and demonstrated that it acts as a partial competitive inhibitor of bradykinin in isolated rat uterine tissue.

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Abstract

1. Significant inhibition of oedema formation caused by thermal injury was observed for calcium carbaspirin, phenylbutazone, hydrocortisone, cryogenine and indomethacin when given daily beginning 2 days prior to thermal exposure and afterwards. Several anti-inflammatory drugs, including cryogenine, failed to reduce thermal oedema significantly when given as single doses 1 h prior to the thermal injury.2. Kinetic experiments on the rat isolated uterus demonstrated that cryogenine, chlorpromazine, and flufenamic acid were, in part, competitive inhibitors of synthetic bradykinin, while indomethacin and tetrabenazine showed only non-competitive antagonism.

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MeSH descriptors

Alkaloids Anti-Inflammatory Agents Edema Quinolizines Uterus Alkaloids Alkaloids Animals Anti-Inflammatory Agents Anti-Inflammatory Agents Benzocaine Benzocaine Bradykinin Bradykinin Burns Burns Chlorpromazine Chlorpromazine Dose-Response Relationship, Drug Edema

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