Epigenética de la endometriosis y su perspectiva terapéutica en el marco de un sistema integral de atención de la infertilidad: revisión y propuesta de investigación

Alejandro Leal Esquivel, Fabio Alfaro Albertazzi, José M. Uribe Salazar
In: Medicina U.P.B. · 2016 · vol. 34(1) , pp. 61–69 · W2509641757
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This review discusses epigenetic patterns in endometriosis and proposes research into their therapeutic potential within integrated infertility care.

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Abstract

Endometriosis consists in the ectopic presence of endometrial glands and stromal cells outside the uterine cavity (mainly in ovaries and on the surface of internal organs of the pelvic cavity). It is one of the most common benign gynecological disorders in reproductive-age women. There are various theories to explain endometriosis. The most widely accepted theory is known as “retrograde menstruation”. Common endometriosis symptoms include pelvic or abdominal pain, dysmenorrhea, dyspareunia, heavy menstrual bleeding, non-menstrual pelvic pain, ovulation pain, dyschezia, dysuria, chornic fatigue syndrome, and fertility problems. Various studies have associated endometriosis with the onset of ovarian cancer, with carcinoma development in 5 to 10% of women with ovarian endometriomas. The successful development of therapeutic strategies to control endometriosis depends on a correct identification of the epigenetic patterns and gene candidates to be targeted by treatment.

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Condition tags

endometriosisdysmenorrheadyspareunia

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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