Comparison of peritoneal oxidative stress during laparoscopy and laparotomy

Ângela Mara Bentes de Souza, Angela M Bentes de Souza, Michael Scott Rogers, Michael S. Rogers, Chi Chiu Wang, Pong Mo Yuen, Pui Shan Ng
The Journal of the American Association of Gynecologic Laparoscopists · 2003 · vol. 10(1) , pp. 65–74 · doi:10.1016/s1074-3804(05)60237-x · PMID:12554997 · W1977729946
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This study compared peritoneal oxidative stress levels between laparoscopic and open surgical procedures in rats.

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Abstract

STUDY OBJECTIVE: To identify oxidative stress in peritoneum during laparoscopic and open surgery by measuring products of lipid peroxidation, and to determine whether surgical approach influences the type of oxidative metabolite synthesized. DESIGN: Retrospective analysis (Canadian Task Force classification II-2). SETTING: University-affiliated hospital. PATIENTS: Twenty-eight consecutive women with uterine myomas or ovarian cysts. INTERVENTION: Laparoscopic or open surgery (14 patients each). MEASUREMENTS AND MAIN RESULTS: We obtained 1 x 1-cm squares of peritoneum at the beginning and end of surgical procedures away from sites of surgery. 8-Isoprostaglandin F(2alpha), hydroxyeicosatetranoic acids (HETEs), and malondyaldehyde (MDA) were measured by enzyme-immunoassay, high-performance liquid chromatography, and thiobarbituric acid adduction method, respectively. Comparisons showed significant increases in 5-HETE and 8-prostane in the laparoscopy group, which were correlated with duration of pneumoperitoneum and volume of carbon dioxide (CO(2)) insufflated, respectively. In the laparotomy group only MDA rose significantly related to duration of surgery. CONCLUSIONS: Lipid peroxidation was observed in peripheral peritoneum during laparoscopic surgery, mediated through noncyclooxygenase and lipoxygenase pathways, and appears to be due to effects of CO(2) pneumoperitoneum. Biochemical reactions were also observed in the laparotomy group, but are thought to be related to mechanisms other than lipid peroxidation.

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MeSH descriptors

Laparoscopy Laparotomy Oxidative Stress Adult Chromatography, High Pressure Liquid Cohort Studies Dinoprost Dinoprost Enzyme-Linked Immunosorbent Assay Female Humans Hydroxyeicosatetraenoic Acids Hydroxyeicosatetraenoic Acids Laparoscopy Laparoscopy Laparotomy Laparotomy Leiomyoma Leiomyoma Leiomyoma

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