Cost–effectiveness of elagolix versus leuprolide acetate for treating moderate-to-severe endometriosis pain in the USA

Si‐Tien Wang, Si-Tien Wang, Scott J Johnson, Dominic Mitchell, Ahmed M Soliman, Jamie Vora, Jamie B Vora, Sanjay K Agarwal
Journal of comparative effectiveness research · 2019 · vol. 8(5) , pp. 337–355 · doi:10.2217/cer-2018-0124 · PMID:30724096 · W2912011793
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Elagolix was cost-effective compared to leuprolide acetate for treating moderate-to-severe endometriosis pain in the US over 1- and 2-year time horizons, showing positive net monetary benefits.

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Abstract

AIM: To assess the cost-effectiveness of elagolix versus leuprolide acetate in women with moderate to severe endometriosis pain. METHODS: A Markov model was developed. The efficacy of leuprolide acetate was derived from statistical prediction models using elagolix trial data. Model inputs were extracted from Phase III clinical trials and published literature. RESULTS: Compared with leuprolide acetate, elagolix generated positive net monetary benefit (NMB) assuming a payer's willingness-to-pay threshold of US$100,000 per quality-adjusted life year over a 1-year time horizon: US$5660 for elagolix 150 mg and US$6443 for elagolix 200 mg. The 2-year NMBs were also positive. CONCLUSION: Elagolix was cost effective versus leuprolide acetate in the management of moderate to severe endometriosis pain over 1- and 2-year time horizons. Results were robust in sensitivity analyses.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Fertility Agents, Female Hydrocarbons, Fluorinated Leuprolide Pyrimidines Adolescent Adult Cost-Benefit Analysis Endometriosis Endometriosis Female Fertility Agents, Female Fertility Agents, Female Humans Hydrocarbons, Fluorinated Hydrocarbons, Fluorinated Leuprolide Leuprolide Markov Chains Middle Aged

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (53)

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