Diagnostische Tests für Endometriose

S. Dogan, A. Agic, W. Frenzel, D. Finas, K. Diedrich, Daniela Hornung
In: Gynäkologische Endokrinologie · 2006 · vol. 4(3) , pp. 128–132 · doi:10.1007/s10304-006-0151-z · W2313528983
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

The determination of CCR1 mRNA from peripheral blood leukocytes is proposed as a new diagnostic test for endometriosis, unlike less sensitive markers like CA 125.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

The paper discusses diagnostic approaches for endometriosis, noting that laparoscopy with histological confirmation remains the “gold standard,” while there is a need for a non-invasive test with high sensitivity and specificity for early disease. It reviews the utility and limitations of several proposed biomarkers, including CA-125, which is not suitable for detecting minimal or mild endometriosis and has low sensitivity, alongside other candidates such as TNF-α, interleukin-6, luteinizing hormone, leukocyte subtypes, haptoglobin beta chain isoform E, Thomsen-Friedenreich antigens, and eosinophil peroxidase. The authors’ group recommends measuring CCR1 (cognate chemokine receptor 1) mRNA from peripheral blood leukocytes as a new diagnostic test. This paper is centrally about endometriosis — it focuses on diagnostic tests and proposes CCR1 mRNA from peripheral blood as a non-invasive alternative.

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