Studies on Prostaglandin Production Relating to the Mechanism of Dysmenorrhea in Endometriosis

Hiroyuki Koike, H Koike, T Ikenoue, Tsuyomu Ikenoue, N Mori, Norimasa Mori
Nihon Naibunpi Gakkai zasshi · 1994 · vol. 70(1) , pp. 43–56 · doi:10.1507/endocrine1927.70.1_43 · PMID:7958083 · W2329093321
article OA: bronze CC0 ⤵ 8 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher

Abstract

The relationship between prostaglandins (PGs) production and the mechanism of dysmenorrhea in endometriosis is poorly understood. Consequently, we investigated the role of PGs in dysmenorrhea of endometriosis. Slices of normal endometrium, normal myometrium, adenomyosis, leiomyoma, normal ovary and affected ovary were incubated. 6-keto PGF1 alpha (a metabolite of PGI2), TXB2 (a metabolite of TXA2), PGF2 alpha and PGE2 concentrations of the incubation medium were measured by RIA. The results are as follows; 1) PGs production in endometriosis was significantly higher than that of other tissues, especially 6-keto PGF1 alpha, which was a dominant product in adenomyosis. 2) There were significant differences in PGs production between severe dysmenorrhea and non dysmenorrhea, especially tissue of adenomyosis with severe dysmenorrhea which produces large amounts of 6-keto PGF1 alpha. 3) There seems to be interaction between normal endometrium and normal myometrium with regard to 6-keto PGF1 alpha production. We concluded that increased PGI2 in the tissue of endometriosis seems to induce hyperalgesia during menstruation.

My notes (saved in your browser only)

Condition tags

mesh:D004412mesh:D004715endometriosisadenomyosisdysmenorrhea

MeSH descriptors

Dysmenorrhea Endometriosis Prostaglandins 6-Ketoprostaglandin F1 alpha 6-Ketoprostaglandin F1 alpha Adult Dinoprost Dinoprost Dinoprostone Dinoprostone Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometrium Endometrium Epoprostenol Epoprostenol Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (7)

Cited by (8)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:11:29.222973+00:00
License: CC0 · commercial use OK