Cost-effectiveness analysis in the treatment of heavy menstrual bleeding in Spain

Joaquím Calaf, J Calaf, I. Lete, Iñaki Lete, Ignasi Canals, I Canals, C Crespo, Carlos Crespo, B. Espinós, Ignacio Cristóbal García, I. Cristóbal
European journal of obstetrics, gynecology, and reproductive biology · 2014 · vol. 184 , pp. 24–31 · doi:10.1016/j.ejogrb.2014.10.034 · PMID:25462215 · W2011873923
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This cost-effectiveness analysis compared different treatment options for heavy menstrual bleeding in Spain.

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Abstract

OBJECTIVE: To compare the effectiveness and costs associated with first-line medical treatments for chronic heavy menstrual bleeding (HMB) in Spain. STUDY DESIGN: A cost-effectiveness analysis was conducted comparing the levonorgestrel-releasing intrauterine system (LNG-IUS) with the estradiol valerate/dienogest multiphase oral contraceptive (E2V/DNG), combined oral contraceptives (COC) and progestins (PROG). Study patients were fertile women diagnosed with HMB who initially wished to remain fertile. A Markov model based on reported clinical data and the opinion of a panel of experts was used. The time horizon of the analysis was 5 years. The analysis was conducted from the perspective of the Spanish National Health System (NHS), discounting both costs (€ 2013) and future effects at an annual rate of 3%. One-way sensitivity analyses and probabilistic sensitivity analysis were performed to test the robustness of the results. RESULTS: In the analysis at 5 years, the LNG-IUS was associated with a gain of 0.67, 2.22, and 3.53 symptoms free months (SFM) compared with E2V/DNG, COC and PROG, respectively. LNG-IUS contributed more quality-adjusted life months (QALM) than the other treatment alternatives (+1.74 vs. E2V/DNG, +3.33 vs. COC +3.53 vs. PROG). First-line LNG-IUS treatment resulted in savings of € 583, € 988, and € 1891 vs. E2V/DNG, COC and PROG, respectively. These cost benefits, coupled with the greater clinical benefits in terms of SFM and QALM, show that LNG-IUS is the dominant option (less costly and more effective). CONCLUSION: LNG-IUS is the medical treatment of choice and cost-saving option for the control of HMB in Spain.

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MeSH descriptors

Contraceptives, Oral, Combined Cost-Benefit Analysis Estradiol Intrauterine Devices, Medicated Levonorgestrel Menorrhagia Nandrolone Contraceptives, Oral, Combined Contraceptives, Oral, Combined Drug Combinations Estradiol Estradiol Estradiol Female Humans Intrauterine Devices, Medicated Levonorgestrel Levonorgestrel Menorrhagia Menorrhagia

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