Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis

Tiziana Genovese, Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Sebastiano Caudullo, Emanuela Raffone, Francesco Macrı̀, Francesco Macrí, Livia Interdonato, Enrico Gugliandolo, Claudia Interlandi, Rosalia Crupi, Ramona D’Amico, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
International journal of molecular sciences · 2022 · vol. 23(10) , pp. 5427 · doi:10.3390/ijms23105427 · PMID:35628240 · W4280534316
article OA: gold CC0 ⤵ 15 in-corpus citations
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Cannabidiol administration in an endometriosis model reduced lesion size and improved markers of oxidative stress, inflammation, fibrosis, and pain.

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Abstract

Endometriosis is usually associated with inflammation and chronic pelvic pain. This paper focuses the attention on the anti-inflammatory, anti-oxidant and analgesic effects of cannabidiol (CBD) and on its potential role in endometriosis. We employed an in vivo model of endometriosis and administered CBD daily by gavage. CBD administration strongly reduced lesions diameter, volume and area. In particular, it was able to modify lesion morphology, reducing epithelial glands and stroma. CBD showed anti-oxidant effects reducing lipid peroxidation, the expression of Nox-1 and Nox-4 enzymes. CBD restored the oxidative equilibrium of the endogenous cellular defense as showed by the SOD activity and the GSH levels in the lesions. CBD also showed important antifibrotic effects as showed by the Masson trichrome staining and by downregulated expression of MMP-9, iNOS and TGF-β. CBD was able to reduce inflammation both in the harvested lesions, as showed by the increased Ikb-α and reduced COX2 cytosolic expressions and reduced NFkB nuclear localization, and in the peritoneal fluids as showed by the decreased TNF-α, PGE2 and IL-1α levels. CBD has important analgesic effects as showed by the reduced mast cells recruitment in the spinal cord and the reduced release of neuro-sensitizing and pro-inflammatory mediators. In conclusion, the collected data showed that CBD has an effective and coordinated effects in endometriosis suppression.

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Condition tags

mesh:D004715endometriosischronic_pelvic_pain

MeSH descriptors

Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Cannabidiol Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (15)

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