Monitoring of CD59 expression in paroxysmal nocturnal hemoglobinuria treated with danazol

Y Katayama, Yoshio Katayama, Y Hiramatsu, K Kohriyama
American journal of hematology · 2001 · vol. 68(4) , pp. 280–283 · doi:10.1002/ajh.10007 · PMID:11754418 · W2004708426
Case report OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

Danazol treatment increased hemoglobin and platelet levels in a PNH patient, leading to transfusion independence, but did not decrease PNH clone size, suggesting danazol also stimulates PNH clone proliferation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

We describe a 52-year-old man with paroxysmal nocturnal hemoglobinuria (PNH) and a moderate transfusion requirement. Prior to and during sequential therapy with androgen (metenolone), glucocorticoid, and danazol, we evaluated CD59-negative expression (PNH clone) in red blood cells, neutrophils, lymphocyte subsets, and bone marrow (BM) CD34(+) cells. Although androgen and glucocorticoid were not effective for recovery of blood cell counts, the hemoglobin and platelet levels increased immediately after the therapy with danazol and the patient became transfusion independent. However, neither the serum level of LDH nor the percentage of PNH clone in each cell lineage, including BM CD34(+) cells, decreased. The number of nucleated cells in BM increased drastically after the start of danazol. These findings suggest that the efficacy of danazol was not only due to the impediment of hemolysis but also due to stimulation of PNH clone proliferation in BM.

My notes (saved in your browser only)

MeSH descriptors

CD59 Antigens Danazol Estrogen Antagonists Hemoglobinuria, Paroxysmal Blood Cells Blood Cells Bone Marrow Cells Bone Marrow Cells CD59 Antigens Cell Count Clone Cells Clone Cells Danazol Danazol Estrogen Antagonists Estrogen Antagonists Hemoglobinuria, Paroxysmal Hemoglobinuria, Paroxysmal Hemoglobinuria, Paroxysmal Humans

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

Cited by (1)

References (8)

Cited by (1)

Source provenance

openalex
last seen: 2026-05-11T05:56:47.744056+00:00
pubmed
last seen: 2026-10-08T21:00:15.595027+00:00
License: CC0 · commercial use OK