In vitro effects of peroxisome proliferator-activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells

Indu Sharma, Veena Dhawan, Dhawan V, Subhash Chand Saha, Saha SC, Lakhbir Kaur Dhaliwal, Dhaliwal LK
Fertility and sterility · 2011 · vol. 95(2) , pp. 829–31.e1-5 · doi:10.1016/j.fertnstert.2010.09.008 · PMID:20970133
Lab / animal OA: closed public-domain-us
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⚙ AI-generated summary by qwen3.7-flash, 2026-08-27 ⓘ

This in vitro study compared the anti-inflammatory effects of rosiglitazone and 15d-PGJ2 on lipopolysaccharide-induced endometrial and endometriotic stromal cells, highlighting peroxisome proliferator-activated receptor-gamma as a potential therapeutic target for endometriosis.

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Abstract

This in vitro study demonstrates the comparative anti-inflammatory effects of rosiglitazone and 15d-PGJ(2) in endometriosis and provides evidence for exploitation of peroxisome proliferator-activated receptor-γ as a therapeutic target.

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Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents Endometrium Gene Expression Lipopolysaccharides PPAR gamma Stromal Cells Anti-Inflammatory Agents Anti-Inflammatory Agents Biopsy Biopsy Case-Control Studies Case-Control Studies Cells, Cultured Cells, Cultured Drug Evaluation, Preclinical Drug Evaluation, Preclinical Endometriosis Endometriosis Endometriosis Endometrium

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europepmc
last seen: 2026-10-23T06:08:06.940705+00:00
pubmed
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