Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis

Vida Kocbek, Katja Vouk, Michael D Mueller, Tea Lanišnik Rižner, Nick A Bersinger
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2013 · vol. 29(5) , pp. 455–459 · doi:10.3109/09513590.2013.769516 · PMID:23461865 · W2056280262
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Women with ovarian endometriosis exhibit significantly higher serum and peritoneal fluid glycodelin-A concentrations, which correlate with menstrual pain and show diagnostic potential as a biomarker.

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Abstract

The aim of this study was to evaluate serum and peritoneal fluid (PF) glycodelin-A concentrations in women with ovarian endometriosis. Ninety-nine matched pairs of serum and PF samples were included in our study. The case group comprised 57 women with ovarian endometriosis and the control group 42 healthy women undergoing sterilization or patients with benign ovarian cysts. Glycodelin-A concentrations were measured using ELISA. Endometriosis patients had significantly higher serum and PF glycodelin-A concentrations compared to controls, and this increase was observed in both proliferative and secretory cycle phases. Glycodelin-A concentrations were more than 10-fold higher in PF than in serum and correlated with each other. Intensity and frequency of menstrual pain positively correlated with glycodelin-A concentrations. Sensitivity and specificity of glycodelin-A as a biomarker for ovarian endometriosis were 82.1% and 78.4% in serum, and 79.7% and 77.5% in PF, respectively. These results indicate that Glycodelin-A has a potential role as a biomarker to be used in combination with other, independent marker molecules.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Glycoproteins Ovarian Diseases Adult Ascitic Fluid Biomarkers Biomarkers Case-Control Studies Endometriosis Female Glycodelin Glycoproteins Humans Ovarian Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (38)

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