Mixed apocrine/endocrine ductal carcinoma in situ of the breast coexistent with lobular carcinoma in situ

Coyne JD, J D Coyne, P A Dervan, Dervan PA, L Barr, Barr L, A D Baildam, Baildam AD
Journal of clinical pathology · 2001 · vol. 54(1) , pp. 70–3 · doi:10.1136/jcp.54.1.70 · PMID:11271793 · PMC1731276
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This case report describes mixed apocrine and endocrine ductal carcinoma in situ coexisting with lobular carcinoma in situ, highlighting unusual biphenotypic morphology and potential biological relationships between these breast lesions.

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Abstract

An unusual mixed form of ductal carcinoma in situ (DCIS) of the breast is described, which exhibits a biphenotypic morphology encompassing a range of differential diagnostic DCIS subtypes. In addition, immunophenotypic and ultrastructural studies demonstrate neuroendocrine and apocrine differentiation, raising questions regarding appropriate classification and biological behaviour. In two cases, coexistence of this mixed form of DCIS with lobular carcinoma in situ (LCIS) in the same duct lobular units is an additional unusual feature that might, at least in some cases, indicate a closer relation between them.

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MeSH descriptors

Breast Neoplasms Carcinoma, Ductal, Breast Carcinoma in Situ Carcinoma, Lobular Neoplasms, Multiple Primary Apocrine Glands Apocrine Glands Breast Neoplasms Carcinoma, Ductal, Breast Carcinoma in Situ Carcinoma, Lobular Cell Differentiation Female Humans Middle Aged Neoplasms, Multiple Primary

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europepmc
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pubmed
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